Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. PRKAR1A, protein kinase, cAMP-dependent, regulatory, type I, alpha
Sequence ID:NM_002734
NM_212471
NM_212472
RefSeqGene ID:NG_007093
Entrez Gene ID:5573
Ensembl ID:ENSG00000108946

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
ACRODYSOSTOSIS 1, WITH OR WITHOUT HORMONE RESISTANCE 
CARNEY COMPLEX, TYPE 1 
MYXOMA, INTRACARDIAC 
PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 1 
THYROID CARCINOMA, PAPILLARYCCDC6
GOLGA5
NCOA4
NCOA4
PCM1
TRIM24
TRIM33

Cytogenetic Location (from UniGene)

Cytogenetic Location:17q23-q24Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:17: 66508590 - 66528900

 Exon Info From UCSC:
NM_002734
NM_212471
NM_212472

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4340015Full LengthBC036285protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
6514677Full LengthBC093042protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_997637  NP_997636  NP_002725  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_002734 NP_002725 P10644 cNMP_binding
RIIa
NM_212471 NP_997636 P10644 cNMP_binding
RIIa
NM_212472 NP_997637 P10644 cNMP_binding
RIIa

Related Sequences

 
mRNAGenPeptSwissProt
M33336 AAB50921 P10644
M18468 AAB50922 P10644
BC036285 AAH36285 P10644
BC093042 AAH93042 P10644
DQ891775 ABM82701  
DQ894959 ABM85885  
AK312307 BAG35232 B2R5T5
AK097580 BAG53489 B2R5T5
A12295 CAA01027 P10644
Y07642 CAA68925 P10644
CR749311 CAH18166 Q68DQ4

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PRKAR1A NP_002725 M.musculus Prkar1a 19084 Gene Info NP_068680 97
R.norvegicus Prkar1a 25725   NP_037313 97
P.falciparum PKAr 811274   XP_001350628 43

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta