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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. POLR2A, Polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
Sequence ID:NM_000937
RefSeqGene ID:NG_027747
Entrez Gene ID:5430
Ensembl ID:ENSG00000181222

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:17p13.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:17: 7387688 - 7417496

 Exon Info From UCSC:
NM_000937

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
9021228Full LengthBC137231polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000928  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000937 NP_000928 P24928 EC 2.7.7.6
EC 2.7.7.48
RNA_pol_Rpb1_2
RNA_pol_Rpb1_3
RNA_pol_Rpb1_7
RNA_pol_Rpb1_6
RNA_pol_Rpb1_1
RNA_pol_Rpb1_5
RNA_pol_Rpb1_4
RNA_pol_Rpb1_R

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M21610 AAA60135 Q15161  
BC067295 AAH67295 Q6NX41  
BC137231 AAI37232 P24928 EC 2.7.7.6
EC 2.7.7.48
AK293777 BAG57192 B4DET1  
AK304882 BAG65619    
X63564 CAA45125 P24928 EC 2.7.7.6
EC 2.7.7.48

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens POLR2A NP_000928 M.musculus Polr2a 20020 Gene Info NP_033115 100
R.norvegicus Polr2a 363633   XP_343923 100
A.gambiae AgaP_AGAP007810 1278148   XP_317690 76
D.melanogaster RpII215 32100   NP_511124 75
C.elegans ama-1 177190   NP_500523 72
A.thaliana NRPB1 829734   NP_195305 62
S.pombe rpb1 2540292   NP_595673 61
S.cerevisiae RPO21 851415   NP_010141 57
N.crassa NCU02103 3880246   XP_964097 53
P.falciparum PFC0805w 814496   XP_001351252 50

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)