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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. ARHGEF12, Rho guanine nucleotide exchange factor (GEF) 12
Sequence ID:NM_001198665
NM_015313
RefSeqGene ID:NG_027960
Entrez Gene ID:23365
Ensembl ID:ENSG00000196914

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, pineal gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, testis, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
LEUKEMIA, ACUTE MYELOGENOUSCBFB
CEBPA
CHIC2
ETV6
FLT3
GATA2
GMPS
JAK2
KIT
LPP
MLF1
MLLT10
NPM1
NSD1
NUP214
PICALM
RUNX1
RUNX1
SH3GL1
TERT
WHSC1L1

Cytogenetic Location (from UniGene)

Cytogenetic Location:11q23.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:11: 120292516 - 120359737


Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
30353240IncompleteBC063117Rho guanine nucleotide exchange factor (GEF) 12
100016177BC152900Rho guanine nucleotide exchange factor (GEF) 12

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_056128  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001198665 NP_001185594    
NM_015313 NP_056128 Q9NZN5 PDZ
RhoGEF

Related Sequences

 
mRNAGenPeptSwissProt
AF180681 AAF36817 Q9NZN5
AF119898 AAF69652 Q9P149
BC063117 AAH63117 Q9NZN5
BC152900 AAI52901  
AB002380 BAA20836 Q9NZN5
AK294803 BAG57923 B4DGW2
AK304316 BAG65168 B4E2K6

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens ARHGEF12 NP_056128 M.musculus Arhgef12 69632 Gene Info NP_081420 89
R.norvegicus Arhgef12 367072   NP_001013264 89

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)