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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. CHEK1, checkpoint kinase 1
Sequence ID:NM_001114121
RefSeqGene ID:NG_030049
Entrez Gene ID:1111
Ensembl ID:ENSG00000149554

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

Cytogenetic Location (from UniGene)

Cytogenetic Location:11q24.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:11: 125496663 - 125525213

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3530606Full LengthBC004202CHK1 checkpoint homolog (S. pombe)
4091997Full LengthBC017575CHK1 checkpoint homolog (S. pombe)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_001265  

Protein Infomation

NM_001114121 NP_001107593      
NM_001114122 NP_001107594      
NM_001244846 NP_001231775      
NM_001274 NP_001265 O14757 EC Pkinase

Related Sequences

AF032874 AAB88852 O14757 EC
AF016582 AAC51736 O14757 EC
BC004202 AAH04202 O14757 EC
BC017575 AAH17575 O14757 EC
DQ892907 ABM83833    
DQ896142 ABM87141    
JF289264 AEB71796 O14757 EC
AK292549 BAF85238 O14757 EC
AK293143 BAG56691 B4DDD0  
AK299783 BAG61665 O14757 EC
AK300082 BAG61885 B4DT73  
AB451222 BAG70036 O14757 EC
AB451345 BAG70159 O14757 EC

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens CHEK1 NP_001265 R.norvegicus Chek1 140583   NP_536325 94
M.musculus Chek1 12649 Gene Info NP_031717 93
A.gambiae AgaP_AGAP008118 1277834   XP_317338 55
D.melanogaster grp 34993   NP_477011 50
C.elegans chk-1 3565921   NP_001024233 41
N.crassa NCU08346 3881389   XP_965249 36
S.pombe chk1 2539087   NP_588070 34
S.cerevisiae CHK1 852577   NP_009833 34

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta