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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. SMC3, structural maintenance of chromosomes 3
Sequence ID:NM_005445
RefSeqGene ID:NG_012217
Entrez Gene ID:9126
Ensembl ID:ENSG00000108055

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, pituitary gland, placenta, pooled tissue, prostate, skin, soft tissue, stem cell, stomach, synovium, t-cell, testis, thymus, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:10q25Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:10: 112327483 - 112364392

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5493263Full LengthBC047324structural maintenance of chromosomes 3

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005436  

Protein Infomation

NM_005445 NP_005436 Q9UQE7 SMC_N

Related Sequences

AF020043 AAC14893 Q9UQE7
AF067163 AAD32447 Q9UQE7
BC047324 AAH47324 Q86VX4
AK289771 BAF82460 Q9UQE7
AK315845 BAF98736 B0AZQ4
AJ005015 CAA06289 Q9UQE7

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens SMC3 NP_005436 M.musculus Smc3 13006 Gene Info NP_031816 100
R.norvegicus Smc3 29486   NP_113771 100
A.gambiae AgaP_AGAP006388 1277000   XP_316422 55
D.melanogaster Cap 32627   NP_523374 54
C.elegans smc-3 176559   NP_001129842 42
A.thaliana TTN7 817259   NP_180285 40
S.pombe psm3 2543010   NP_593260 40
N.crassa NCU07554 3874026   XP_957879 39
S.cerevisiae SMC3 853371   NP_012461 35

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)