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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. POLR2E, polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
Sequence ID:NM_002695
Entrez Gene ID:5434
Ensembl ID:ENSG00000099817

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:19p13.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:19: 1088165 - 1095374

NM_002695 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2820565Full LengthBC004441polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
4617000Full LengthBC034144polymerase (RNA) II (DNA directed) polypeptide E, 25kDa

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002686  

Protein Infomation

NM_002695 NP_002686 P19388 RNA_pol_Rpb5_C

Related Sequences

J04965 AAA62401 P19388
S42643 AAB19339 P19388
BC004441 AAH04441 P19388
BC034144 AAH34144 P19388
HQ448367 ADQ32847  
D38251 BAA07406 P19388
AK312625 BAG35511 P19388
AK295975 BAG58751 B4DJ89

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens POLR2E NP_002686 M.musculus Polr2e 66420 Gene Info NP_079830 99
R.norvegicus Polr2e 690966   NP_001103084 99
A.gambiae AgaP_AGAP010064 1279496   XP_319221 86
D.melanogaster Rpb5 36160   NP_610630 86
A.thaliana NRPB5 821801   NP_188871 55
S.cerevisiae RPB5 852451   NP_009712 48
P.falciparum PF13_0341 814300   XP_001350359 48
S.pombe rpb5 2541910   NP_593187 46
N.crassa NCU05305 3878224   XP_962076 41

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)