Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. CDKN1B, cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Sequence ID:NM_004064
RefSeqGene ID:NG_016341
Entrez Gene ID:1027
Ensembl ID:ENSG00000111276

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, t-cell, testis, thymus, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
MULTIPLE ENDOCRINE NEOPLASIA, TYPE IV 

Cytogenetic Location (from UniGene)

Cytogenetic Location:12p13.1-p12Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:12: 12870773 - 12871880

NM_004064 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
19471287030112871247
94810771287175812871887
107824131287396912875304

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3458141Full LengthBC001971cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_004055  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_004064 NP_004055 Q6I9V6
P46527
CDI

Related Sequences

 
mRNAGenPeptSwissProt
U10906 AAA20240 Q6I9V6
P46527
AF247551 AAF69497 Q9NYG6
AY004255 AAF88142 Q96TE0
BC001971 AAH01971 P46527
BT019553 AAV38360 P46527
BT019554 AAV38361 P46527
AK312461 BAG35368 Q6I9V6
AK298335 BAG60584 B4DPH2
AB451291 BAG70105 Q6I9V6
AB451423 BAG70237 Q6I9V6
AJ616234 CAE82383 Q708J1
CR457399 CAG33680 Q6I9V6
P46527
AM392564 CAL37442  
AM393540 CAL38417  
AM393634 CAL38510  
AM393862 CAL38737  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens CDKN1B NP_004055 M.musculus Cdkn1b 12576 Gene Info NP_034005 88
R.norvegicus Cdkn1b 83571   NP_113950 87

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta