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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. RRM2, ribonucleotide reductase M2
Sequence ID:NM_001034
NM_001165931
Entrez Gene ID:6241
Ensembl ID:ENSG00000171848

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, placenta, pooled tissue, prostate, salivary gland, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:2p25-p24Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:2: 10262865 - 10271351

 Exon Info From UCSC:
NM_001034
NM_001165931

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3528619Full LengthBC001886ribonucleotide reductase M2 polypeptide
4858919Full LengthBC030154ribonucleotide reductase M2 polypeptide
5140388IncompleteBC028932ribonucleotide reductase M2 polypeptide

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_001025  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001034 NP_001025 P31350 EC 1.17.4.1 Ribonuc_red_sm
NM_001165931 NP_001159403      

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
S40301 AAA09577 P31350 EC 1.17.4.1
BC001886 AAH01886 P31350 EC 1.17.4.1
BC028932 AAH28932 Q8N6S3  
BC030154 AAH30154 P31350 EC 1.17.4.1
DQ891863 ABM82789    
DQ895052 ABM85978    
AK313719 BAG36462 P31350 EC 1.17.4.1
AK092671 BAG52588 B3KS26  
AK123010 BAG53847 B3KS26  
X59618 CAA42181 P31350 EC 1.17.4.1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens RRM2 NP_001159403 M.musculus Rrm2 20135 Gene Info NP_033130 92
R.norvegicus Rrm2 362720   NP_001020911 90
R.norvegicus LOC100359539 100359539   XP_002728627 90
A.gambiae AgaP_AGAP006818 1270247   XP_308927 83
D.melanogaster RnrS 36280   NP_525111 82
S.pombe suc22 2540381   NP_596546 71
S.cerevisiae RNR2 853427   NP_012508 70
C.elegans rnr-2 175525   NP_497821 70
N.crassa NCU07887 3878959   XP_962820 69
A.thaliana RNR2A 821937   NP_189000 66

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)