Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. PROC, Protein C (inactivator of coagulation factors Va and VIIIa)
Sequence ID:NM_000312
RefSeqGene ID:NG_016323
Entrez Gene ID:5624
Ensembl ID:ENSG00000115718

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
THROMBOPHILIA DUE TO PROTEIN C DEFICIENCY, AUTOSOMAL DOMINANT 
THROMBOPHILIA DUE TO PROTEIN C DEFICIENCY, AUTOSOMAL RECESSIVE 

Cytogenetic Location (from UniGene)

Cytogenetic Location:2q13-q14Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:2: 128176008 - 128186821

NM_000312 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
173128175995128176067
74164128177497128177587
165331128178858128179024
332356128180492128180516
357494128180609128180746
495629128180849128180983
630772128183660128183802
773890128184680128184797
8911779128185932128186820

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5188604Full LengthBC034377protein C (inactivator of coagulation factors Va and VIIIa)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000303  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000312 NP_000303 P04070 EC 3.4.21.69 EGF
Trypsin
Gla

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
K02059 AAA60164 P04070 EC 3.4.21.69
S50739 AAB24150    
BC034377 AAH34377 P04070 EC 3.4.21.69
DQ890791 ABM81717    
DQ893947 ABM84873    
AK298280 BAG60540 B4DPC8  
AK298449 BAG60665 B4DPQ3  
AK298454 BAG60669 B4DPQ7  
AK303773 BAG64736 B4E1C4  
X02750 CAA26528 P04070 EC 3.4.21.69

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PROC NP_000303 M.musculus Proc 19123 Gene Info NP_001036232 70
R.norvegicus Proc 25268   NP_036935 70

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta