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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. PRF1, perforin 1 (pore forming protein)
Sequence ID:NM_001083116
NM_005041
RefSeqGene ID:NG_009615
Entrez Gene ID:5551
Ensembl ID:ENSG00000180644

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 2 
LYMPHOMA, NON-HODGKINCASP10
RAD54L

Cytogenetic Location (from UniGene)

Cytogenetic Location:10q22Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:10: 72357766 - 72358707

 Exon Info From UCSC:
NM_001083116
NM_005041

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5748582Full LengthBC063043perforin 1 (pore forming protein)
5752084Full LengthBC047695perforin 1 (pore forming protein)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005032  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001083116 NP_001076585    
NM_005041 NP_005032 P14222 C2
MACPF

Related Sequences

 
mRNAGenPeptSwissProt
M28393 AAA60065 P14222
L40557 AAA63618 P14222
BC047695 AAH47695 P14222
BC063043 AAH63043 P14222
FJ555237 ACU25794 E6Y8C6
AB209604 BAD92841 P14222
AK312754 BAG35621 P14222
X13224 CAA31612 P14222

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PRF1 NP_001076585 R.norvegicus Prf1 50669   NP_059026 69
M.musculus Prf1 18646 Gene Info NP_035203 69

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta