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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. A2M, alpha-2-macroglobulin
Sequence ID:NM_000014
RefSeqGene ID:NG_011717
Entrez Gene ID:2
Ensembl ID:ENSG00000175899

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
ALZHEIMER DISEASEACE
APBB2
APP
BLMH
HFE
MPO
NOS3
PAXIP1
PLAU
SORL1

Cytogenetic Location (from UniGene)

Cytogenetic Location:12p13.31Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:12: 9220303 - 9268469

 Exon Info From UCSC:
NM_000014

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
6056126Full LengthBC040071alpha-2-macroglobulin

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000005  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000014 NP_000005 P01023 A2M
A2M_N
A2M_recep
A2M_comp
A2M_N_2

Related Sequences

 
mRNAGenPeptSwissProt
M11313 AAA51551 P01023
M36501 AAA51552 P01023
BC026246 AAH26246 P01023
BC040071 AAH40071 P01023
AY591530 AAT02228 P01023
AB209614 BAD92851 P01023
CR749334 CAH18188 P01023

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens A2M NP_000005 R.norvegicus A2m 24153   NP_036620 74
M.musculus A2m 232345 Gene Info NP_783327 73

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)