Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. ECE1, endothelin converting enzyme 1
Sequence ID:NM_001113347
NM_001113348
NM_001113349
NM_001397
RefSeqGene ID:NG_013008
Entrez Gene ID:1889
Ensembl ID:ENSG00000117298

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, synovium, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
HIRSCHSPRUNG DISEASE, CARDIAC DEFECTS, AND AUTONOMIC DYSFUNCTION 
HYPERTENSIONADD1
AGT
AGTR1
AGTR1
ATP1B1
ATP1B1
CYP3A5
GNB3
NOS2
NOS3
PTGIS
RGS5
RGS5
SELE

Cytogenetic Location (from UniGene)

Cytogenetic Location:1p36.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 21546074 - 21616649

 Exon Info From UCSC:
NM_001113347
NM_001113348
NM_001113349
NM_001397

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
8991973Full LengthBC126257endothelin converting enzyme 1
40125807Full LengthBC117256endothelin converting enzyme 1

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_001388  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001113347 NP_001106818      
NM_001113348 NP_001106819      
NM_001113349 NP_001106820      
NM_001397 NP_001388 P42892 EC 3.4.24.71 Peptidase_M13
Peptidase_M13_N

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
BC117256 AAI17257 P42892 EC 3.4.24.71
BC126257 AAI26258 P42892 EC 3.4.24.71
HQ258359 ADR83113    
D43698 BAA07800 P42892 EC 3.4.24.71
D49471 BAA08442 P42892 EC 3.4.24.71
AB031742 BAA83687 P42892 EC 3.4.24.71
AK290656 BAF83345 P42892 EC 3.4.24.71
AK296486 BAG59124 B4DKB2  
AK304167 BAG65053 P42892 EC 3.4.24.71
X98272 CAA66922 P42892 EC 3.4.24.71
Z35307 CAA84548 P42892 EC 3.4.24.71
AJ130828 CAB46443 P42892 EC 3.4.24.71

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens ECE1 NP_001388 M.musculus Ece1 230857 Gene Info NP_955011 96
R.norvegicus Ece1 94204   NP_446048 95
A.gambiae AgaP_AGAP007796 1278166   XP_317711 48
D.melanogaster Nep3 33005   NP_523417 46

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)