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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. PPP1CA, protein phosphatase 1, catalytic subunit, alpha isozyme
Sequence ID:NM_001008709
Entrez Gene ID:5499
Ensembl ID:ENSG00000172531

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:11q13Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:11: 67165651 - 67188615

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3528742Full LengthBC008010protein phosphatase 1, catalytic subunit, alpha isoform
3546588Full LengthBC001888protein phosphatase 1, catalytic subunit, alpha isoform
3689198Full LengthBC004482protein phosphatase 1, catalytic subunit, alpha isoform

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002699  NP_001008709  NP_996756  

Protein Infomation

NM_001008709 NP_001008709     Metallophos
NM_002708 NP_002699 P62136 EC Metallophos
NM_206873 NP_996756     Metallophos

Related Sequences

J04759 AAA36475 P62136 EC
M63960 AAA36508 P62136 EC
S57501 AAB26015 P62136 EC
BC001888 AAH01888 P62136 EC
BC004482 AAH04482 P62136 EC
BC008010 AAH08010 P62136 EC
BT006629 AAP35275 P62136 EC
AK313586 BAG36355 P62136 EC
AK127616 BAG54534 B3KXM2  
X70848 CAA50197 P62136 EC

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens PPP1CA NP_001008709 M.musculus Ppp1ca 19045 Gene Info NP_114074 100
R.norvegicus Ppp1ca 24668   NP_113715 100
C.elegans gsp-2 3564807   NP_001022616 91
A.gambiae AgaP_AGAP011166 1270763   XP_309483 89
D.melanogaster Pp1alpha-96A 42922   NP_524484 89
N.crassa NCU00043 3872306   XP_956154 87
S.cerevisiae GLC7 856870   NP_011059 86
S.pombe dis2 2541193   NP_596317 85
A.thaliana TOPP2 836034   NP_001032103 81
A.thaliana TOPP5 823835   NP_190266 80

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)