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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. PARP1, poly (ADP-ribose) polymerase 1
Sequence ID:NM_001618
Entrez Gene ID:142
Ensembl ID:ENSG00000143799

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:1q41-q42Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 226576399 - 226578197

 Exon Info From UCSC:
NM_001618

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5193735Full LengthBC037545poly (ADP-ribose) polymerase 1
4643426IncompleteBC014206poly (ADP-ribose) polymerase 1
5015448IncompleteBC018620poly (ADP-ribose) polymerase 1

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_001609  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001618 NP_001609 P09874 EC 2.4.2.30 BRCT
PARP
zf-PARP
PARP_reg
WGR
PADR1

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M17081 AAA51599 P09874 EC 2.4.2.30
M18112 AAA60137 P09874 EC 2.4.2.30
M32721 AAA60155 P09874 EC 2.4.2.30
J03473 AAB59447 P09874 EC 2.4.2.30
BC014206 AAH14206 Q6PJL0  
BC018620 AAH18620 Q05D33  
BC037545 AAH37545 P09874 EC 2.4.2.30
AF401218 AAL02174 Q96P95  
DQ891636 ABM82562    
DQ894826 ABM85752    
AK312339 BAG35260 B2R5W3  
AK303340 BAG64403 B4E0E1  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PARP1 NP_001609 M.musculus Parp1 11545 Gene Info NP_031441 93
R.norvegicus Parp1 25591   NP_037195 92
A.gambiae AgaP_AGAP003230 1273904   XP_312938 46
D.melanogaster Parp 3355109   NP_001104452 44
A.thaliana PARP2 817690   NP_850165 42
C.elegans pme-1 266823   NP_491072 41

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta