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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. LIG1, ligase I, DNA, ATP-dependent
Sequence ID:NM_000234
RefSeqGene ID:NG_007395
Entrez Gene ID:3978
Ensembl ID:ENSG00000105486

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:19q13.2-q13.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:19: 48618706 - 48673583

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
6141535Full LengthBC108318ligase I, DNA, ATP-dependent
40035687Full LengthBC110622ligase I, DNA, ATP-dependent

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000225  

Protein Infomation

NM_000234 NP_000225 P18858 EC DNA_ligase_A_M

Related Sequences

M36067 AAA59518 P18858 EC
BC108318 AAI08319 P18858 EC
BC110622 AAI10623 Q2TB12  
AB208791 BAD92028 Q59HG7  
AK314210 BAG36885 P18858 EC
AK297296 BAG59764 B4DM52  
AK300370 BAG62106 B4DTU4  
AK300607 BAG62303 B4DUE1  
AK303644 BAG64647 B4E135  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens LIG1 NP_000225 M.musculus Lig1 16881 Gene Info NP_001076657 84
R.norvegicus Lig1 81513   NP_001019439 84
A.gambiae AgaP_AGAP009222 1280180   XP_319999 55
D.melanogaster CG5602 37791   NP_611843 52
A.thaliana LIG1 837333   NP_172293 51
C.elegans lig-1 179502   NP_741625 51
S.pombe cdc17 2541849   NP_593318 50
A.thaliana AT1G49250 841349   NP_175351 48
N.crassa NCU06481 3873294   XP_957121 47
S.cerevisiae CDC9 851391   NP_010117 44

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)