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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. TLR4, toll-like receptor 4
Sequence ID:NM_003266
NM_138554
NM_138557
NM_138556
RefSeqGene ID:NG_011475
Entrez Gene ID:7099
Ensembl ID:ENSG00000136869

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
COLON CANCERAKT1
APC
APC
AURKA
AXIN2
BCL10
BUB1B
CCND1
EP300
FGFR3
FLCN
MLH3
NRAS
ODC1
PDGFRL
PIK3CA
PIK3CA
PLA2G2A
PTPRJ
SMAD7
TLR2
TP53
TP53
MACULAR DEGENERATION, AGE-RELATED,10 

Cytogenetic Location (from UniGene)

Cytogenetic Location:9q33.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:9: 120466750 - 120476926

Transcript StartTranscript EndChromosomal Start Chromosomal End
1384120466459120466842
385551120470840120471006
5525649120474666120479763

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
40125973Full LengthBC117422toll-like receptor 4

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_612567  NP_612564  NP_003257  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_003266 NP_003257   LRR_1
TIR
NM_138554 NP_612564 O00206 LRR_1
TIR
NM_138557 NP_612567   LRR_1
TIR

Related Sequences

 
mRNAGenPeptSwissProt
U88880 AAC34135 O00206
U93091 AAC80227 O00206
BC117422 AAI17423 O00206
AK290053 BAF82742 O00206
AK293068 BAF85757 O00206
AB445638 BAG55035 O00206
AK303730 BAG64706 O00206

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens TLR4 NP_612564 M.musculus Tlr4 21898 Gene Info NP_067272 68
R.norvegicus Tlr4 29260   NP_062051 67

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)