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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. LIG4, ligase IV, DNA, ATP-dependent
Sequence ID:NM_001098268
NM_002312
NM_206937
RefSeqGene ID:NG_007396
Entrez Gene ID:3981
Ensembl ID:ENSG00000174405

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
MULTIPLE MYELOMACCND1
IRF4
SEVERE COMBINED IMMUNODEFICIENCY, ATHABASCAN TYPEDCLRE1C

Cytogenetic Location (from UniGene)

Cytogenetic Location:13q33-q34Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:13: 108859793 - 108867871

 Exon Info From UCSC:
NM_001098268
NM_002312
NM_206937

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5259632Full LengthBC037491ligase IV, DNA, ATP-dependent

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002303  NP_996820  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001098268 NP_001091738      
NM_002312 NP_002303 P49917 EC 6.5.1.1 BRCT
DNA_ligase_A_M
DNA_ligase_A_C
NM_206937 NP_996820     BRCT
DNA_ligase_A_M
DNA_ligase_A_C

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
BC037491 AAH37491 P49917 EC 6.5.1.1
DQ892474 ABM83400    
DQ895686 ABM86612    
AK292419 BAF85108 A8K8Q4  
AK314844 BAG37361 B2RBW4  
X83441 CAA58467 P49917 EC 6.5.1.1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens LIG4 NP_001091738 M.musculus Lig4 319583 Gene Info NP_795927 87
R.norvegicus Lig4 290907   NP_001099565 86
A.thaliana ATLIG4 835822   NP_568851 34
D.melanogaster Lig4 32322   NP_572907 34
S.pombe lig4 2539042   NP_587888 33
N.crassa NCU06264 3879007   XP_962868 33
A.gambiae AgaP_AGAP000623 1271687   XP_310455 32
S.cerevisiae DNL4 854166   NP_014647 30

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)