Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. POLE2, polymerase (DNA directed), epsilon 2, accessory subunit
Sequence ID:NM_001197330
NM_001197331
NM_002692
Entrez Gene ID:5427
Ensembl ID:ENSG00000100479

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesRNAi

Gene Expression Data


Cytogenetic Location (from UniGene)

Cytogenetic Location:14q21-q22Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:14: 50110277 - 50154935


Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
7481939Full LengthBC112962polymerase (DNA directed), epsilon 2 (p59 subunit)
8991934Full LengthBC126218polymerase (DNA directed), epsilon 2 (p59 subunit)
8991936Full LengthBC126220polymerase (DNA directed), epsilon 2 (p59 subunit)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002683  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001197330 NP_001184259      
NM_001197331 NP_001184260      
NM_002692 NP_002683 P56282 EC 2.7.7.7 DNA_pol_E_B

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
AF036899 AAC39610 P56282 EC 2.7.7.7
AF025840 AAC51920 P56282 EC 2.7.7.7
BC112962 AAI12963 P56282 EC 2.7.7.7
BC126218 AAI26219 P56282 EC 2.7.7.7
BC126220 AAI26221 P56282 EC 2.7.7.7
HQ258453 ADR83207    
AK293163 BAG56707 P56282 EC 2.7.7.7
BX248064 CAD62358 Q86SY9  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens POLE2 NP_002683 R.norvegicus Pole2 299112   NP_001162579 91
M.musculus Pole2 18974 Gene Info NP_035263 90
D.melanogaster Pole2 38661   NP_647995 43
A.gambiae AgaP_AGAP004614 1275918   XP_315206 42
A.thaliana DPB2 832272   NP_680197 36
N.crassa NCU10155 3874435   XP_958288 36
S.pombe dpb2 2541347   NP_596521 34
S.cerevisiae DPB2 856305   NP_015501 32
C.elegans F08B4.5 177673   NP_501489 31
P.falciparum PFL1655c 811383   XP_001350737 26

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)