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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. APC, adenomatous polyposis coli
Sequence ID:NM_000038
NM_001127510
NM_001127511
RefSeqGene ID:NG_008481
Entrez Gene ID:324
Ensembl ID:ENSG00000134982

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, synovium, testis, thymus, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
ADENOMATOUS POLYPOSIS COLI 
COLON CANCERAKT1
AURKA
AXIN2
BCL10
BUB1B
CCND1
EP300
FGFR3
FLCN
MLH3
NRAS
ODC1
PDGFRL
PIK3CA
PIK3CA
PLA2G2A
PTPRJ
SMAD7
TLR2
TLR4
TP53
TP53
DESMOID DISEASE, HEREDITARY 
GASTRIC CANCER RISK AFTER H. PYLORI INFECTIONCASP10
CDH1
ERBB2
FGFR2
IL1B
IL1RN
IRF1
KLF6
KLF6
KRAS
MUTYH
PIK3CA
PIK3CA
GASTRIC CANCER, SOMATIC 
HEPATOBLASTOMA, SOMATICAXIN1
CASP8
CTNNB1
MET
PDGFRL
PIK3CA
PIK3CA
TP53
TP53
MEDULLOBLASTOMAABR
BRCA2
CTNNB1
DMBT1
PTCH1
PTCH2
SUFU
MISMATCH REPAIR CANCER SYNDROMEMLH1
MSH2
MSH6
PMS2

Cytogenetic Location (from UniGene)

Cytogenetic Location:5q21-q22Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:5: 112073591 - 112181753

 Exon Info From UCSC:
NM_000038
NM_001127510
NM_001127511

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
40080545Full LengthBC111591adenomatous polyposis coli
6744334IncompleteBC056268adenomatous polyposis coli
40080641BC111462adenomatous polyposis coli
40080737BC111930adenomatous polyposis coli
40080833BC113358adenomatosis polyposis coli

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000029  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000038 NP_000029 P25054 Arm
APC_crr
SAMP
EB1_binding
APC_basic
APC_15aa
NM_001127510 NP_001120982    
NM_001127511 NP_001120983    

Related Sequences

 
mRNAGenPeptSwissProt
M74088 AAA03586 P25054
M73548 AAA60353 P25054
M73548 AAA60354 P25054
S67787 AAD13997 Q16097
S67788 AAD13998 Q9UM98
S56365 AAD14918  
BC056268 AAH56268 Q7Z2Q8
BC111462 AAI11463  
BC111591 AAI11592  
BC111930 AAI11931  
AB210001 BAE06083 Q4LE70
AK289567 BAF82256 A8K0K2
AK294544 BAH11802 B7Z2B6

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens APC NP_000029 M.musculus Apc 11789 Gene Info NP_031488 91
R.norvegicus Apc 24205   NP_036631 90

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta