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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. GDF5, growth differentiation factor 5
Sequence ID:NM_000557
RefSeqGene ID:NG_008076
Entrez Gene ID:8200
Ensembl ID:ENSG00000125965

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
ACROMESOMELIC DYSPLASIA, HUNTER-THOMPSON TYPE 
BRACHYDACTYLY, TYPE C 
BRACHYDACTYLY, TYPEA2BMP2
BMPR1B
CHONDRODYSPLASIA, GREBE TYPE 
FIBULAR HYPOPLASIA AND COMPLEX BRACHYDACTYLY 
MULTIPLE SYNOSTOSES SYNDROME 2 
OSTEOARTHRITIS 
SYMPHALANGISM, PROXIMALNOG

Cytogenetic Location (from UniGene)

Cytogenetic Location:20q11.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:20: 34021148 - 34025956

NM_000557 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
114333402114834022580
143423833402507734026026

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5243109Full LengthBC032495growth differentiation factor 5
40010820IncompleteBC111566growth differentiation factor 5
40010823IncompleteBC111859growth differentiation factor 5

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000548  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000557 NP_000548 P43026 TGF_beta
TGFb_propeptide

Related Sequences

 
mRNAGenPeptSwissProt
U13660 AAA57007 P43026
BC032495 AAH32495 P43026
BC111566 AAI11567 Q2NKW7
BC111859 AAI11860 Q2NKW7
EU832171 ACE87521  
HQ257975 ADR82729  
AB593125 BAJ84065 F1T0J1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens GDF5 NP_000548 M.musculus Gdf5 14563 Gene Info NP_032135 93

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)