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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. TOP2A, Topoisomerase (DNA) II alpha 170kDa
Sequence ID:NM_001067
RefSeqGene ID:NG_027678
Entrez Gene ID:7153
Ensembl ID:ENSG00000131747

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Cytogenetic Location (from UniGene)

Cytogenetic Location:17q21-q22Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:17: 38548945 - 38557123

 Exon Info From UCSC:
NM_001067

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
9021659Full LengthBC140791topoisomerase (DNA) II alpha 170kDa
4101949IncompleteBC013429topoisomerase (DNA) II alpha 170kDa

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_001058  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001067 NP_001058 P11388 EC 5.99.1.3 DNA_gyraseB
DNA_topoisoIV
HATPase_c
DTHCT

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
J04088 AAA61209 P11388 EC 5.99.1.3
AF285157 AAG13403 P11388 EC 5.99.1.3
AF285158 AAG13404 P11388 EC 5.99.1.3
AF285159 AAG13405 P11388 EC 5.99.1.3
BC140791 AAI40792 P11388 EC 5.99.1.3

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens TOP2A NP_001058 M.musculus Top2a 21973 Gene Info NP_035753 90
R.norvegicus Top2a 360243   NP_071519 89
A.gambiae AgaP_AGAP008917 1279885   XP_319665 60
D.melanogaster Top2 35225   NP_476760 59
C.elegans top-2 174825   NP_496536 58
S.pombe top2 2540541   NP_595805 48
A.thaliana TOPII 821972   NP_189031 48
S.cerevisiae TOP2 855636   NP_014311 47
P.falciparum PF14_0316 811898   XP_001348490 47
N.crassa NCU06338 3878536   XP_962372 45

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta