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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. EIF2S1, eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Sequence ID:NM_004094
Entrez Gene ID:1965
Ensembl ID:ENSG00000134001

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:14q23.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:14: 67827058 - 67851076

NM_004094 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
11406782703367827172
1413826783148367831724
3834626784118467841263
4636146784315567843306
6157216784737567847481
7228196784830967848406
8209636784916367849306
96441646785003167853231

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3139624Full LengthBC002513eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_004085  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_004094 NP_004085 P05198
Q53XC0
S1
EIF_2_alpha

Related Sequences

 
mRNAGenPeptSwissProt
J02645 AAA52373 P05198
Q53XC0
BC002513 AAH02513 P05198
Q53XC0
DQ892151 ABM83077  
DQ895347 ABM86273  
D28379 BAA05745  
AK312442 BAG35351 Q53XC0
AK297244 BAG59724 B4DM12
BX161521 CAD61953 P05198
Q53XC0

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens EIF2S1 NP_004085 M.musculus Eif2s1 13665 Gene Info NP_080390 99
R.norvegicus Eif2s1 54318   NP_062229 99
A.gambiae AgaP_AGAP011190 1270736   XP_309455 68
D.melanogaster eIF-2alpha 32617   NP_573130 63
C.elegans Y37E3.10 171769   NP_490930 58
S.pombe tif211 2543455   NP_594081 56
S.cerevisiae SUI2 853463   NP_012540 55
N.crassa NCU08277 3878044   XP_961905 54
A.thaliana AT2G40290 818621   NP_565927 51
P.falciparum PF07_0117 2655170   XP_001349177 50
A.thaliana EIF2 ALPHA 830430   NP_196166 49

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta