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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. MAP2K1, mitogen-activated protein kinase kinase 1
Sequence ID:NM_002755
RefSeqGene ID:NG_008305
Entrez Gene ID:5604
Ensembl ID:ENSG00000169032

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, salivary gland, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
CARDIOFACIOCUTANEOUS SYNDROMEBRAF
KRAS
MAP2K2

Cytogenetic Location (from UniGene)

Cytogenetic Location:15q22.1-q22.33Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:15: 66679249 - 66783240

 Exon Info From UCSC:
NM_002755

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
9021459Full LengthBC137459mitogen-activated protein kinase kinase 1
40053655Full LengthBC139729mitogen-activated protein kinase kinase 1

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002746  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_002755 NP_002746 Q02750 EC 2.7.12.2 Pkinase

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
L05624 AAA36318 Q02750 EC 2.7.12.2
BC137459 AAI37460 A4QPA9  
BC139729 AAI39730 A4QPA9  
AK291500 BAF84189 A4QPA9  
AK294322 BAG57596 B4DFY5  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens MAP2K1 NP_002746 M.musculus Map2k1 26395 Gene Info NP_032953 99
R.norvegicus Map2k1 170851   NP_113831 99
A.gambiae AgaP_AGAP001103 1282062   XP_322064 69
D.melanogaster Dsor1 31872   NP_511098 68
C.elegans mek-2 171872   NP_491087 55
A.thaliana MEK1 828713   NP_194337 44
A.thaliana MKK2 829103   NP_001031751 44
S.cerevisiae STE7 851396   NP_010122 42

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta