Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. FGFR3, Fibroblast growth factor receptor 3
Sequence ID:NM_001163213
NM_000142
NM_022965
RefSeqGene ID:NG_012632
Entrez Gene ID:2261
Ensembl ID:ENSG00000068078

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
ACHONDROPLASIA 
BLADDER CANCER, SOMATICHRAS
KRAS
LOC100270680
RB1
TACC3
CATSHL SYNDROME 
CERVICAL CANCER, SOMATIC 
COLON CANCERAKT1
APC
APC
AURKA
AXIN2
BCL10
BUB1B
CCND1
EP300
FLCN
MLH3
NRAS
ODC1
PDGFRL
PIK3CA
PIK3CA
PLA2G2A
PTPRJ
SMAD7
TLR2
TLR4
TP53
TP53
CROUZON SYNDROME WITH ACANTHOSIS NIGRICANS 
GERM CELL TUMORSBCL10
KIT
STK11
HYPOCHONDROPLASIA 
LADD SYNDROMEFGF10
FGFR2
MUENKE SYNDROME 
NEVUS SEBACEOUS, SOMATICHRAS
PIK3CA
PIK3CA
THANATOPHORIC DYSPLASIA, TYPE I 
THANATOPHORIC DYSPLASIA, TYPE II 

Cytogenetic Location (from UniGene)

Cytogenetic Location:4p16.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:4: 1795033 - 1810592

 Exon Info From UCSC:
NM_001163213
NM_000142
NM_022965

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
100066410Full LengthBC166684fibroblast growth factor receptor 3
40122515IncompleteBC121175fibroblast growth factor receptor 3
40122516IncompleteBC128610fibroblast growth factor receptor 3
40122517IncompleteBC153824fibroblast growth factor receptor 3

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000133  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000142 NP_000133 P22607 EC 2.7.10.1 ig
I-set
Pkinase_Tyr
NM_001163213 NP_001156685      
NM_022965 NP_075254      

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M58051 AAA52450 P22607 EC 2.7.10.1
M64347 AAA58470 P22607 EC 2.7.10.1
M59374 AAA63209 P22607 EC 2.7.10.1
AF245114 AAF63380 P22607 EC 2.7.10.1
AF238374 AAF97749 Q9NRB6  
BC121175 AAI21176 Q0IJ44  
BC128610 AAI28611 Q0IJ44  
BC153824 AAI53825 A8E633  
BC166684 AAI66684    
AF369211 AAK54727 Q96T36  
AF369212 AAK54728 Q96T35  
AF369213 AAK54729 Q96T34  
HM244683 ADM64307 I6LM06  
AB209441 BAD92678 P22607 EC 2.7.10.1
X84939 CAA59334 P22607 EC 2.7.10.1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens FGFR3 NP_001156685 M.musculus Fgfr3 14184 Gene Info NP_032036 89
R.norvegicus Fgfr3 84489   NP_445881 89
C.elegans egl-15 181291   NP_001024723 42

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)