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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. DLD, dihydrolipoamide dehydrogenase
Sequence ID:NM_000108
RefSeqGene ID:NG_008045
Entrez Gene ID:1738
Ensembl ID:ENSG00000091140

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
LEIGH SYNDROMEBCS1L
COX15
FOXRED1
NDUFA10
NDUFA12
NDUFA2
NDUFA9
NDUFAF2
NDUFAF6
NDUFS3
NDUFS4
NDUFS7
NDUFS8
NDUFV1
SDHA
SURF1
MAPLE SYRUP URINE DISEASE, TYPE IABCKDHA
BCKDHB
DBT

Cytogenetic Location (from UniGene)

Cytogenetic Location:7q31-q32Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:7: 107531641 - 107560000

 Exon Info From UCSC:
NM_000108

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3029752Full LengthBC018648dihydrolipoamide dehydrogenase
3029752Full LengthBC018696dihydrolipoamide dehydrogenase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000099  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000108 NP_000099 P09622 EC 1.8.1.4 Pyr_redox
Pyr_redox_dim
Pyr_redox_2

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
J03620 AAA35764 P09622 EC 1.8.1.4
J03490 AAA59527 P09622 EC 1.8.1.4
BC018648 AAH18648 P09622 EC 1.8.1.4
BC018696 AAH18696 P09622 EC 1.8.1.4
HQ447584 ADQ32070    
AB209703 BAD92940 P09622 EC 1.8.1.4
AK312346 BAG35267 P09622 EC 1.8.1.4
AK294146 BAG57472 B4DFL1  
AK295080 BAG58122 B4DHG0  
AK297508 BAG59921 B4DMK9  
AK300077 BAG61881 B4DT69  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens DLD NP_000099 R.norvegicus Dld 298942   NP_955417 95
M.musculus Dld 13382 Gene Info NP_031887 95
C.elegans LLC1.3 178387   NP_502753 73
A.gambiae AgaP_AGAP011629 1281003   XP_320877 71
D.melanogaster CG7430 39988   NP_649017 69
A.thaliana mtLPD1 841221   NP_849782 60
A.thaliana mtLPD2 820984   NP_566570 59
S.cerevisiae LPD1 850527   NP_116635 59
S.pombe dld1 2543269   NP_593496 59
N.crassa NCU02407 3875682   XP_959535 56

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)