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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. GNAS, GNAS complex locus
Sequence ID:NM_000516
NM_001077488
NM_001077489
NM_001077490
NM_016592
NM_080425
NM_080426
NR_003259
RefSeqGene ID:NG_016194
Entrez Gene ID:2778
Ensembl ID:ENSG00000087460

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
ACROMEGALYAIP
SSTR5
ACTH-INDEPENDENT MACRONODULAR ADRENAL HYPERPLASIA 
MCCUNE-ALBRIGHT SYNDROME 
OSSEOUS HETEROPLASIA, PROGRESSIVE 
PSEUDOHYPOPARATHYROIDISM IA 
PSEUDOHYPOPARATHYROIDISM IBGNAS-AS1
STX16
PSEUDOHYPOPARATHYROIDISM IC 
PSEUDOPSEUDOHYPOPARATHYROIDISM 

Cytogenetic Location (from UniGene)

Cytogenetic Location:20q13.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:20: 57466781 - 57485884

 Exon Info From UCSC:
NM_000516
NM_001077488
NM_001077489
NM_001077490
NM_016592
NM_080425
NM_080426

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4108909IncompleteBC022875GNAS complex locus

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000507  NP_536350  NP_057676  NP_536351  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000516 NP_000507 P63092 G-alpha
NM_001077488 NP_001070956    
NM_001077489 NP_001070957    
NM_001077490 NP_001070958    
NM_016592 NP_057676 O95467 NESP55
NM_080425 NP_536350 Q5JWF2 Arf
G-alpha
NM_080426 NP_536351   G-alpha

Related Sequences

 
mRNAGenPeptSwissProt
M14631 AAA52583 P63092
AF064092 AAC16860 O60726
AF088184 AAC34896 O75632
AF088185 AAC34897 O75633
AF105253 AAF63226 O95467
BC002722 AAH02722 P63092
BC008855 AAH08855 P63092
BC022875 AAH22875 P63092
BC066923 AAH66923 P63092
BC089157 AAH89157 Q5FWY2
BC104928 AAI04929 P63092
BC108315 AAI08316 P63092
AF493897 AAM12611 P63092
AF493898 AAM12612 P63092
BT009905 AAP88907 P63092
EU832264 ACE86834  
EU832170 ACE87520  
HQ448266 ADQ32746  
AK315860 BAF98751 B0AZR9
AK315874 BAF98765 B0AZR9
AK314549 BAG37135 O95467
AJ224867 CAA12164 Q5JWF2
X04408 CAA27996 P63092
X04409 CAA27997 P63092
X07036 CAA30084 P63092
X56009 CAA39484 Q14455

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens GNAS NP_536350 A.gambiae GNAS_ANOGA 1280580   XP_320433 75
D.melanogaster G-salpha60A 37805   NP_726388 74
C.elegans gsa-1 171687   NP_490817 68

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta