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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. PPP2CA, protein phosphatase 2, catalytic subunit, alpha isozyme
Sequence ID:NM_002715
Entrez Gene ID:5515
Ensembl ID:ENSG00000113575

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:5q31.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:5: 133533462 - 133561552

NM_002715 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
21388133532148133533534
13891507133534776133534894
15081669133536025133536186
16701759133536675133536764
17601933133537538133537711
19342143133541612133541821
21442643133561450133561949

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2822635Full LengthBC000400protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
2822635Full LengthBC019275protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
3607862Full LengthBC002657protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
5001649Full LengthBC031696protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002706  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_002715 NP_002706 P67775 EC 3.1.3.16 Metallophos

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
J03804 AAB38019 P67775 EC 3.1.3.16
BC000400 AAH00400 P67775 EC 3.1.3.16
BC002657 AAH02657 P67775 EC 3.1.3.16
BC019275 AAH19275 P67775 EC 3.1.3.16
BC031696 AAH31696 P67775 EC 3.1.3.16
AK057424 BAG51913 B3KQ51  
AK097599 BAG53493 B3KUN1  
AB451240 BAG70054 B3KUN1  
AB451365 BAG70179 B3KUN1  
X12646 CAA31176 P67775 EC 3.1.3.16
CR457417 CAG33698 Q6I9T8  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PPP2CA NP_002706 M.musculus Ppp2ca 19052 Gene Info NP_062284 100
R.norvegicus Ppp2ca 24672   NP_058735 100
N.crassa NCU06630 3877966   XP_961818 87
A.thaliana PP2A-1 842276   NP_176192 80
A.thaliana PP2A 843333   NP_177154 80
A.thaliana PP2A-2 837583   NP_172514 80
S.pombe ppa2 2540072   NP_595940 80
S.cerevisiae PPH21 851421   NP_010147 76
S.cerevisiae PPH22 851339   NP_010093 76

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta