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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. GZMB, granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Sequence ID:NM_004131
RefSeqGene ID:NG_028340
Entrez Gene ID:3002
Ensembl ID:ENSG00000100453

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Cytogenetic Location (from UniGene)

Cytogenetic Location:14q11.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:14: 25100230 - 25103366

NM_004131 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
162752510016025100419
2765362510106325101323
5376722510152925101664
6738202510212025102267
8219412510331125103431

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5223876Full LengthBC030195granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_004122  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_004131 NP_004122 P10144 EC 3.4.21.79 Trypsin

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
J03189 AAA36603 P10144 EC 3.4.21.79
M17016 AAA36627 P10144 EC 3.4.21.79
J04071 AAA52118 P10144 EC 3.4.21.79
BC030195 AAH30195 P10144 EC 3.4.21.79
AY232654 AAP70244 Q6XGZ4  
AY232655 AAP70245 Q6XGZ3  
AY232656 AAP70246 Q6XGZ2  
AY372494 AAR23323 Q67BC3  
EU176524 ABW03325    

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens GZMB NP_004122 R.norvegicus Gzmb 171528   NP_612526 70
M.musculus Gzmb 14939 Gene Info NP_038570 69
R.norvegicus RGD1561819 502004   XP_577431 67
R.norvegicus LOC100361468 100361468   XP_002728303 65
R.norvegicus LOC100361261 100361261   XP_002728331 64

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta