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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. EZH2, Enhancer of zeste homolog 2 (Drosophila)
Sequence ID:NM_004456
NM_001203247
NM_001203249
NM_001203248
NM_152998
RefSeqGene ID:NG_032043
Entrez Gene ID:2146
Ensembl ID:ENSG00000106462

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
WEAVER SYNDROME 2 

Cytogenetic Location (from UniGene)

Cytogenetic Location:7q35-q36Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:7: 148504476 - 148581340

 Exon Info From UCSC:
NM_004456
NM_152998

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3901250Full LengthBC010858enhancer of zeste homolog 2 (Drosophila)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_004447  NP_694543  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001203247 NP_001190176 Q15910 EC 2.1.1.43  
NM_001203248 NP_001190177      
NM_001203249 NP_001190178      
NM_004456 NP_004447     SET
NM_152998 NP_694543     SET

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
U61145 AAC51520 Q15910 EC 2.1.1.43
BC010858 AAH10858 Q15910 EC 2.1.1.43
AY519465 AAS09975 Q6R125  
DQ894179 ABM85105    
JF327843 AEA07595 F2YMM1  
AB208895 BAD92132 Q59H64  
AK314291 BAG36948 Q15910 EC 2.1.1.43
AK092676 BAG52592 Q15910 EC 2.1.1.43
AK293239 BAH11472 Q15910 EC 2.1.1.43
AK302216 BAH13652 Q15910 EC 2.1.1.43
AK303585 BAH13991 B7Z8K5  
AK303637 BAH14002 B7Z8L6  
X95653 CAA64955 Q15910 EC 2.1.1.43

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens EZH2 NP_004447 M.musculus Ezh2 14056 Gene Info NP_001140161 98
R.norvegicus Ezh2 312299   NP_001128451 98
D.melanogaster E(z) 39203   NP_001137932 62
A.gambiae AgaP_AGAP012516 1268848   XP_307419 61

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta