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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

The Recurrent Chromosome Aberrations in Cancer Database Searcher
  • Brief instructions for searching the database:
    • You must choose one or both of the following two fields: Structural Aberrations and Numerical Aberrations.
    • If you choose Structural Aberrations, you must select at least one of the following fields: Breakpoint, Topography, Morphology, or Gene.
    • If you choose Numerical Aberrations, you must select at least one of the following fields: Chromosome, Topography, Morphology.
    • You may select only one item in each pulldown menu
    • Press Retrieve.
  • A successful search returns a table, with the following headings and entries:
    • Breakpoint, with each entry linked to the OMIM Gene Map (this column is returned only for structural aberrations)
    • Abnormality
    • Morphology, with each entry linked to a similar table that describes all abnormalities with this morphology.
    • Topography, with each entry linked to a similar table that describes all abnormalities at this topography
    • Number of cases, hyperlinked to the list of applicable cases
    • Genes

Aberration type:
Aberration type:




Expand Topography List:

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[Full Text]

Balanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
11q13 ins(10;11)(p12;q23q13) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/MLLT10
11q13 t(10;11)(p13;q13) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q14 t(10;11)(p13;q14) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q23 ins(10;11)(p12;q23q13) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/MLLT10
11q23 t(10;11)(p11;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A+
11q23 t(10;11)(p12;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/ABI1,KMT2A/MLLT10,KMT2A+
11q23 t(11;16)(q23;q24) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/USP10
11q23 t(11;17)(q23;q12) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/MLLT6
11q23 t(11;17)(q23;q21) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A+
11q23 t(11;19)(q23;p13) Acute monoblastic leukemia without differentiation (FAB type M5a)   28  KMT2A/MLLT1,KMT2A+
11q23 t(1;11)(p32;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/EPS15,KMT2A+
11q23 t(4;11)(q21;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q23 t(6;11)(q27;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   14  KMT2A/MLLT4,KMT2A+
11q23 t(9;11)(p21;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   32  KMT2A/MLLT3,KMT2A+
11q23 t(9;11)(p22;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   45   
11q24 t(9;11)(p22;q24) Acute monoblastic leukemia without differentiation (FAB type M5a)    

Unbalanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
11p15 add(11)(p15) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q13 der(10)t(10;11)(p12;q23)inv(11)(q13q23) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q23 add(11)(q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A+
11q23 del(11)(q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/ARHGEF12
11q23 del(11)(q23q24) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q23 der(10)t(10;11)(p12;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q23 der(10)t(10;11)(p12;q23)inv(11)(q13q23) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q23 der(10)t(10;11)(p12;q23)inv(11)(q13q23) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q24 del(11)(q23q24) Acute monoblastic leukemia without differentiation (FAB type M5a)    

Numerical Chromosomal Trisomy Abnormalities

Abnormality Morphology Topography Cases Genes
+1 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+2 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+3 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+4 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+5 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+6 Acute monoblastic leukemia without differentiation (FAB type M5a)   12   
+7 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+8 Acute monoblastic leukemia without differentiation (FAB type M5a)   109   
+9 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+11 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+12 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+13 Acute monoblastic leukemia without differentiation (FAB type M5a)   12   
+14 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+15 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+16 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+18 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+19 Acute monoblastic leukemia without differentiation (FAB type M5a)   19   
+20 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+21 Acute monoblastic leukemia without differentiation (FAB type M5a)   15   
+22 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+X Acute monoblastic leukemia without differentiation (FAB type M5a)    
+Y Acute monoblastic leukemia without differentiation (FAB type M5a)    

Numerical Chromosomal Monosomy Abnormalities

Abnormality Morphology Topography Cases Genes
-2 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-3 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-4 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-5 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-6 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-7 Acute monoblastic leukemia without differentiation (FAB type M5a)   18   
-9 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-10 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-11 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-12 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-13 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-15 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-16 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-17 Acute monoblastic leukemia without differentiation (FAB type M5a)   10   
-18 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-20 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-21 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-22 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-X Acute monoblastic leukemia without differentiation (FAB type M5a)    
-Y Acute monoblastic leukemia without differentiation (FAB type M5a)   14