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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

The Recurrent Chromosome Aberrations in Cancer Database Searcher
  • Brief instructions for searching the database:
    • You must choose one or both of the following two fields: Structural Aberrations and Numerical Aberrations.
    • If you choose Structural Aberrations, you must select at least one of the following fields: Breakpoint, Topography, Morphology, or Gene.
    • If you choose Numerical Aberrations, you must select at least one of the following fields: Chromosome, Topography, Morphology.
    • You may select only one item in each pulldown menu
    • Press Retrieve.
  • A successful search returns a table, with the following headings and entries:
    • Breakpoint, with each entry linked to the OMIM Gene Map (this column is returned only for structural aberrations)
    • Abnormality
    • Morphology, with each entry linked to a similar table that describes all abnormalities with this morphology.
    • Topography, with each entry linked to a similar table that describes all abnormalities at this topography
    • Number of cases, hyperlinked to the list of applicable cases
    • Genes

Aberration type:
Aberration type:




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[Full Text]

Balanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
11p15 inv(11)(p15q22) Acute myelomonocytic leukemia (FAB type M4)   NUP98/DDX10
11p15 inv(11)(p15q23) Acute myelomonocytic leukemia (FAB type M4)   KMT2A+
11p15 t(11;12)(p15;q13) Acute myelomonocytic leukemia (FAB type M4)   NUP98/HOXC13
11p15 t(2;11)(q31;p15) Acute myelomonocytic leukemia (FAB type M4)   NUP98/HOXD11,NUP98/HOXD13
11p15 t(3;11)(p11;p15) Acute myelomonocytic leukemia (FAB type M4)   NUP98/POU1F1
11p15 t(5;11)(q35;p15) Acute myelomonocytic leukemia (FAB type M4)   10  NSD1/NUP98,NUP98/NSD1
11p15 t(7;11)(p15;p15) Acute myelomonocytic leukemia (FAB type M4)   15  NUP98/HOXA9
11q13 t(10;11)(p14;q13) Acute myelomonocytic leukemia (FAB type M4)    
11q22 inv(11)(p15q22) Acute myelomonocytic leukemia (FAB type M4)   NUP98/DDX10
11q23 inv(11)(p15q23) Acute myelomonocytic leukemia (FAB type M4)   KMT2A+
11q23 t(10;11)(p11;q23) Acute myelomonocytic leukemia (FAB type M4)   KMT2A+
11q23 t(10;11)(p12;q23) Acute myelomonocytic leukemia (FAB type M4)   KMT2A/ABI1,KMT2A/MLLT10,MLLT10/KMT2A
11q23 t(10;11)(p13;q23) Acute myelomonocytic leukemia (FAB type M4)   KMT2A+
11q23 t(10;11)(q22;q23) Acute myelomonocytic leukemia (FAB type M4)   KMT2A+
11q23 t(11;12)(q23;q13) Acute myelomonocytic leukemia (FAB type M4)   KMT2A/SARNP
11q23 t(11;15)(q23;q12) Acute myelomonocytic leukemia (FAB type M4)    
11q23 t(11;16)(q23;p13) Acute myelomonocytic leukemia (FAB type M4)   KMT2A/CREBBP
11q23 t(11;17)(q23;q21) Acute myelomonocytic leukemia (FAB type M4)   13  KMT2A+
11q23 t(11;17)(q23;q25) Acute myelomonocytic leukemia (FAB type M4)   11  KMT2A/SEPT9,KMT2A+
11q23 t(11;19)(q23;p13) Acute myelomonocytic leukemia (FAB type M4)   43  KMT2A/ELL,KMT2A/MLLT1,KMT2A+
11q23 t(11;19)(q23;q13) Acute myelomonocytic leukemia (FAB type M4)    
11q23 t(11;22)(q23;q11) Acute myelomonocytic leukemia (FAB type M4)   KMT2A+
11q23 t(11;22)(q23;q12) Acute myelomonocytic leukemia (FAB type M4)    
11q23 t(1;11)(p32;q23) Acute myelomonocytic leukemia (FAB type M4)   KMT2A/EPS15,KMT2A+
11q23 t(1;11)(q21;q23) Acute myelomonocytic leukemia (FAB type M4)   13  KMT2A/MLLT11,KMT2A+
11q23 t(2;11)(p21;q23) Acute myelomonocytic leukemia (FAB type M4)    
11q23 t(2;11)(q37;q23) Acute myelomonocytic leukemia (FAB type M4)   KMT2A/SEPT2
11q23 t(4;11)(q21;q23) Acute myelomonocytic leukemia (FAB type M4)   10  KMT2A/AFF1
11q23 t(6;11)(q27;q23) Acute myelomonocytic leukemia (FAB type M4)   30  KMT2A/MLLT4,KMT2A+
11q23 t(9;11)(p21;q23) Acute myelomonocytic leukemia (FAB type M4)   20  KMT2A/MLLT3,KMT2A+
11q23 t(9;11)(p22;q23) Acute myelomonocytic leukemia (FAB type M4)   37   
11q23 t(X;11)(q13;q23) Acute myelomonocytic leukemia (FAB type M4)   KMT2A/FOXO4

Unbalanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
11p12 del(11)(p12p14) Acute myelomonocytic leukemia (FAB type M4)    
11p13 del(11)(p13) Acute myelomonocytic leukemia (FAB type M4)    
11p14 del(11)(p12p14) Acute myelomonocytic leukemia (FAB type M4)    
11p15 add(11)(p15) Acute myelomonocytic leukemia (FAB type M4)    
11q10 i(11)(q10) Acute myelomonocytic leukemia (FAB type M4)    
11q13 del(11)(q13) Acute myelomonocytic leukemia (FAB type M4)    
11q13 del(11)(q13q23) Acute myelomonocytic leukemia (FAB type M4)    
11q13 der(1)t(1;11)(q21;q23)t(1;11)(p12;q25)ins(1;11)(p32;q13q23) Acute myelomonocytic leukemia (FAB type M4)    
11q13 der(10)t(10;11)(p12;q23)inv(11)(q13q23) Acute myelomonocytic leukemia (FAB type M4)    
11q13 der(11)t(1;11)(q21;q23)del(11)(q13q23) Acute myelomonocytic leukemia (FAB type M4)    
11q14 del(11)(q14) Acute myelomonocytic leukemia (FAB type M4)    
11q14 del(11)(q14q23) Acute myelomonocytic leukemia (FAB type M4)    
11q21 del(11)(q21) Acute myelomonocytic leukemia (FAB type M4)    
11q23 add(11)(q23) Acute myelomonocytic leukemia (FAB type M4)   11   
11q23 del(11)(q13q23) Acute myelomonocytic leukemia (FAB type M4)    
11q23 del(11)(q14q23) Acute myelomonocytic leukemia (FAB type M4)    
11q23 del(11)(q23) Acute myelomonocytic leukemia (FAB type M4)   24  KMT2A+,KMT2A/ARHGEF12
11q23 del(11)(q23q25) Acute myelomonocytic leukemia (FAB type M4)   KMT2A+
11q23 der(1)t(1;11)(q21;q23)t(1;11)(p12;q25)ins(1;11)(p32;q13q23) Acute myelomonocytic leukemia (FAB type M4)    
11q23 der(1)t(1;11)(q21;q23)t(1;11)(p12;q25)ins(1;11)(p32;q13q23) Acute myelomonocytic leukemia (FAB type M4)    
11q23 der(10)t(10;11)(p12;q23)inv(11)(q13q23) Acute myelomonocytic leukemia (FAB type M4)    
11q23 der(10)t(10;11)(p12;q23)inv(11)(q13q23) Acute myelomonocytic leukemia (FAB type M4)    
11q23 der(11)t(1;11)(q21;q23)del(11)(q13q23) Acute myelomonocytic leukemia (FAB type M4)    
11q23 der(11)t(1;11)(q21;q23)del(11)(q13q23) Acute myelomonocytic leukemia (FAB type M4)    
11q24 add(11)(q24) Acute myelomonocytic leukemia (FAB type M4)    
11q25 del(11)(q23q25) Acute myelomonocytic leukemia (FAB type M4)   KMT2A+
11q25 der(1)t(1;11)(q21;q23)t(1;11)(p12;q25)ins(1;11)(p32;q13q23) Acute myelomonocytic leukemia (FAB type M4)    

Numerical Chromosomal Trisomy Abnormalities

Abnormality Morphology Topography Cases Genes
+1 Acute myelomonocytic leukemia (FAB type M4)   32   
+2 Acute myelomonocytic leukemia (FAB type M4)    
+3 Acute myelomonocytic leukemia (FAB type M4)   10   
+4 Acute myelomonocytic leukemia (FAB type M4)   52   
+5 Acute myelomonocytic leukemia (FAB type M4)   14   
+6 Acute myelomonocytic leukemia (FAB type M4)   46   
+7 Acute myelomonocytic leukemia (FAB type M4)   12   
+8 Acute myelomonocytic leukemia (FAB type M4)   339   
+9 Acute myelomonocytic leukemia (FAB type M4)   41   
+10 Acute myelomonocytic leukemia (FAB type M4)   27   
+11 Acute myelomonocytic leukemia (FAB type M4)   56   
+12 Acute myelomonocytic leukemia (FAB type M4)   19   
+13 Acute myelomonocytic leukemia (FAB type M4)   59   
+14 Acute myelomonocytic leukemia (FAB type M4)   24   
+15 Acute myelomonocytic leukemia (FAB type M4)   23   
+16 Acute myelomonocytic leukemia (FAB type M4)   10   
+17 Acute myelomonocytic leukemia (FAB type M4)   16   
+18 Acute myelomonocytic leukemia (FAB type M4)   20   
+19 Acute myelomonocytic leukemia (FAB type M4)   46   
+20 Acute myelomonocytic leukemia (FAB type M4)   32   
+21 Acute myelomonocytic leukemia (FAB type M4)   114   
+22 Acute myelomonocytic leukemia (FAB type M4)   161   
+X Acute myelomonocytic leukemia (FAB type M4)   16   
+Y Acute myelomonocytic leukemia (FAB type M4)   13   

Numerical Chromosomal Monosomy Abnormalities

Abnormality Morphology Topography Cases Genes
-1 Acute myelomonocytic leukemia (FAB type M4)    
-2 Acute myelomonocytic leukemia (FAB type M4)   13   
-3 Acute myelomonocytic leukemia (FAB type M4)   17   
-4 Acute myelomonocytic leukemia (FAB type M4)    
-5 Acute myelomonocytic leukemia (FAB type M4)   53   
-6 Acute myelomonocytic leukemia (FAB type M4)   17   
-7 Acute myelomonocytic leukemia (FAB type M4)   225   
-8 Acute myelomonocytic leukemia (FAB type M4)   21   
-9 Acute myelomonocytic leukemia (FAB type M4)   27   
-10 Acute myelomonocytic leukemia (FAB type M4)   15   
-11 Acute myelomonocytic leukemia (FAB type M4)   17   
-12 Acute myelomonocytic leukemia (FAB type M4)   32   
-13 Acute myelomonocytic leukemia (FAB type M4)   41   
-14 Acute myelomonocytic leukemia (FAB type M4)   20   
-15 Acute myelomonocytic leukemia (FAB type M4)   34   
-16 Acute myelomonocytic leukemia (FAB type M4)   47   
-17 Acute myelomonocytic leukemia (FAB type M4)   75   
-18 Acute myelomonocytic leukemia (FAB type M4)   57   
-19 Acute myelomonocytic leukemia (FAB type M4)   19   
-20 Acute myelomonocytic leukemia (FAB type M4)   35   
-21 Acute myelomonocytic leukemia (FAB type M4)   52   
-22 Acute myelomonocytic leukemia (FAB type M4)   23   
-X Acute myelomonocytic leukemia (FAB type M4)   28   
-Y Acute myelomonocytic leukemia (FAB type M4)   74