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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

The Recurrent Chromosome Aberrations in Cancer Database Searcher
  • Brief instructions for searching the database:
    • You must choose one or both of the following two fields: Structural Aberrations and Numerical Aberrations.
    • If you choose Structural Aberrations, you must select at least one of the following fields: Breakpoint, Topography, Morphology, or Gene.
    • If you choose Numerical Aberrations, you must select at least one of the following fields: Chromosome, Topography, Morphology.
    • You may select only one item in each pulldown menu
    • Press Retrieve.
  • A successful search returns a table, with the following headings and entries:
    • Breakpoint, with each entry linked to the OMIM Gene Map (this column is returned only for structural aberrations)
    • Abnormality
    • Morphology, with each entry linked to a similar table that describes all abnormalities with this morphology.
    • Topography, with each entry linked to a similar table that describes all abnormalities at this topography
    • Number of cases, hyperlinked to the list of applicable cases
    • Genes

Aberration type:
Aberration type:




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[Full Text]

Balanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
11p15 inv(11)(p15q23) Acute myeloblastic leukemia with maturation (FAB type M2)   NUP98/KMT2A
11p15 t(11;12)(p15;q13) Acute myeloblastic leukemia with maturation (FAB type M2)   NUP98/HOXC11,NUP98/HOXC13
11p15 t(11;20)(p15;q11) Acute myeloblastic leukemia with maturation (FAB type M2)    
11p15 t(1;11)(q23;p15) Acute myeloblastic leukemia with maturation (FAB type M2)    
11p15 t(5;11)(q35;p15) Acute myeloblastic leukemia with maturation (FAB type M2)   NSD1/NUP98,NUP98/NSD1
11p15 t(7;11)(p15;p15) Acute myeloblastic leukemia with maturation (FAB type M2)   40  NUP98/HOXA11,NUP98/HOXA13,NUP98/HOXA9
11p15 t(8;11;21)(q22;p15;q22) Acute myeloblastic leukemia with maturation (FAB type M2)    
11p15 t(9;11)(p22;p15) Acute myeloblastic leukemia with maturation (FAB type M2)   NUP98/PSIP1
11q13 t(11;16)(q13;p11) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q13 t(5;11)(q35;q13) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q13 t(8;11;21)(q22;q13;q22) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q23 inv(11)(p15q23) Acute myeloblastic leukemia with maturation (FAB type M2)   NUP98/KMT2A
11q23 t(11;15)(q23;q14) Acute myeloblastic leukemia with maturation (FAB type M2)   KMT2A+,KMT2A/CASC5,KMT2A/ZFYVE19
11q23 t(11;17)(q23;q21) Acute myeloblastic leukemia with maturation (FAB type M2)   ZBTB16/RARA
11q23 t(11;17)(q23;q25) Acute myeloblastic leukemia with maturation (FAB type M2)   KMT2A/SEPT9,KMT2A+
11q23 t(11;19)(q23;p13) Acute myeloblastic leukemia with maturation (FAB type M2)   25  KMT2A/ELL,KMT2A/MLLT1,KMT2A+
11q23 t(11;22)(q23;q11) Acute myeloblastic leukemia with maturation (FAB type M2)   KMT2A/SEPT5
11q23 t(1;11)(q21;q23) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q23 t(2;11)(p21;q23) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q23 t(6;11)(q27;q23) Acute myeloblastic leukemia with maturation (FAB type M2)   KMT2A/MLLT4,KMT2A+
11q23 t(9;11)(p21;q23) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q23 t(9;11)(p22;q23) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q23 t(X;11)(q22;q23) Acute myeloblastic leukemia with maturation (FAB type M2)   KMT2A+

Unbalanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
11p11 add(11)(p11) Acute myeloblastic leukemia with maturation (FAB type M2)    
11p11 del(11)(p11p15) Acute myeloblastic leukemia with maturation (FAB type M2)    
11p13 del(11)(p13) Acute myeloblastic leukemia with maturation (FAB type M2)    
11p15 add(11)(p15) Acute myeloblastic leukemia with maturation (FAB type M2)    
11p15 del(11)(p11p15) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q10 i(11)(q10) Acute myeloblastic leukemia with maturation (FAB type M2)   16   
11q13 add(11)(q13) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q13 del(11)(q13) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q13 del(11)(q13q22) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q13 del(11)(q13q23) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q13 der(5)t(5;11)(q35;q13) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q13 der(6)t(6;11)(p21;q13) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q14 add(11)(q14) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q14 del(11)(q14) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q22 del(11)(q13q22) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q22 del(11)(q22) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q22 del(11)(q22q24) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q22 der(9)t(9;11)(q34;q22) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q23 add(11)(q23) Acute myeloblastic leukemia with maturation (FAB type M2)   KMT2A+
11q23 del(11)(q13q23) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q23 del(11)(q23) Acute myeloblastic leukemia with maturation (FAB type M2)   KMT2A+
11q23 hsr(11)(q23) Acute myeloblastic leukemia with maturation (FAB type M2)   +ETS1,+KMT2A,+OPCML
11q24 del(11)(q22q24) Acute myeloblastic leukemia with maturation (FAB type M2)    
11q25 add(11)(q25) Acute myeloblastic leukemia with maturation (FAB type M2)    

Numerical Chromosomal Trisomy Abnormalities

Abnormality Morphology Topography Cases Genes
+1 Acute myeloblastic leukemia with maturation (FAB type M2)   36   
+2 Acute myeloblastic leukemia with maturation (FAB type M2)    
+3 Acute myeloblastic leukemia with maturation (FAB type M2)   11   
+4 Acute myeloblastic leukemia with maturation (FAB type M2)   88   
+5 Acute myeloblastic leukemia with maturation (FAB type M2)   18   
+6 Acute myeloblastic leukemia with maturation (FAB type M2)   46   
+7 Acute myeloblastic leukemia with maturation (FAB type M2)    
+8 Acute myeloblastic leukemia with maturation (FAB type M2)   374   
+9 Acute myeloblastic leukemia with maturation (FAB type M2)   45   
+10 Acute myeloblastic leukemia with maturation (FAB type M2)   54   
+11 Acute myeloblastic leukemia with maturation (FAB type M2)   129   
+12 Acute myeloblastic leukemia with maturation (FAB type M2)   25   
+13 Acute myeloblastic leukemia with maturation (FAB type M2)   78   
+14 Acute myeloblastic leukemia with maturation (FAB type M2)   35   
+15 Acute myeloblastic leukemia with maturation (FAB type M2)   38   
+16 Acute myeloblastic leukemia with maturation (FAB type M2)    
+17 Acute myeloblastic leukemia with maturation (FAB type M2)   10   
+18 Acute myeloblastic leukemia with maturation (FAB type M2)   27   
+19 Acute myeloblastic leukemia with maturation (FAB type M2)   49   
+20 Acute myeloblastic leukemia with maturation (FAB type M2)   21   
+21 Acute myeloblastic leukemia with maturation (FAB type M2)   128   
+22 Acute myeloblastic leukemia with maturation (FAB type M2)   83   
+X Acute myeloblastic leukemia with maturation (FAB type M2)   19   
+Y Acute myeloblastic leukemia with maturation (FAB type M2)   18   

Numerical Chromosomal Monosomy Abnormalities

Abnormality Morphology Topography Cases Genes
-1 Acute myeloblastic leukemia with maturation (FAB type M2)   13   
-2 Acute myeloblastic leukemia with maturation (FAB type M2)   22   
-3 Acute myeloblastic leukemia with maturation (FAB type M2)   59   
-4 Acute myeloblastic leukemia with maturation (FAB type M2)   37   
-5 Acute myeloblastic leukemia with maturation (FAB type M2)   135   
-6 Acute myeloblastic leukemia with maturation (FAB type M2)   31   
-7 Acute myeloblastic leukemia with maturation (FAB type M2)   289   
-8 Acute myeloblastic leukemia with maturation (FAB type M2)   47   
-9 Acute myeloblastic leukemia with maturation (FAB type M2)   46   
-10 Acute myeloblastic leukemia with maturation (FAB type M2)   30   
-11 Acute myeloblastic leukemia with maturation (FAB type M2)   52   
-12 Acute myeloblastic leukemia with maturation (FAB type M2)   58   
-13 Acute myeloblastic leukemia with maturation (FAB type M2)   71   
-14 Acute myeloblastic leukemia with maturation (FAB type M2)   39   
-15 Acute myeloblastic leukemia with maturation (FAB type M2)   57   
-16 Acute myeloblastic leukemia with maturation (FAB type M2)   80   
-17 Acute myeloblastic leukemia with maturation (FAB type M2)   163   
-18 Acute myeloblastic leukemia with maturation (FAB type M2)   117   
-19 Acute myeloblastic leukemia with maturation (FAB type M2)   37   
-20 Acute myeloblastic leukemia with maturation (FAB type M2)   70   
-21 Acute myeloblastic leukemia with maturation (FAB type M2)   99   
-22 Acute myeloblastic leukemia with maturation (FAB type M2)   57   
-X Acute myeloblastic leukemia with maturation (FAB type M2)   236   
-Y Acute myeloblastic leukemia with maturation (FAB type M2)   525