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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

The Recurrent Chromosome Aberrations in Cancer Database Searcher
  • Brief instructions for searching the database:
    • You must choose one or both of the following two fields: Structural Aberrations and Numerical Aberrations.
    • If you choose Structural Aberrations, you must select at least one of the following fields: Breakpoint, Topography, Morphology, or Gene.
    • If you choose Numerical Aberrations, you must select at least one of the following fields: Chromosome, Topography, Morphology.
    • You may select only one item in each pulldown menu
    • Press Retrieve.
  • A successful search returns a table, with the following headings and entries:
    • Breakpoint, with each entry linked to the OMIM Gene Map (this column is returned only for structural aberrations)
    • Abnormality
    • Morphology, with each entry linked to a similar table that describes all abnormalities with this morphology.
    • Topography, with each entry linked to a similar table that describes all abnormalities at this topography
    • Number of cases, hyperlinked to the list of applicable cases
    • Genes

Aberration type:
Aberration type:




Expand Topography List:

Expand Morphology List:

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[Full Text]

Balanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
4q12 t(4;22)(q12;q11) Chronic eosinophilic leukemia/hypereosinophilic syndrome   BCR/PDGFRA
5q31 t(5;12)(q31;p13) Chronic eosinophilic leukemia/hypereosinophilic syndrome    
5q32 t(5;10)(q32;q21) Chronic eosinophilic leukemia/hypereosinophilic syndrome   CCDC6/PDGFRB
8p22 t(8;9)(p22;p23) Chronic eosinophilic leukemia/hypereosinophilic syndrome    
8p22 t(8;9)(p22;p24) Chronic eosinophilic leukemia/hypereosinophilic syndrome   PCM1/JAK2
9p23 t(8;9)(p22;p23) Chronic eosinophilic leukemia/hypereosinophilic syndrome    
9p24 t(8;9)(p22;p24) Chronic eosinophilic leukemia/hypereosinophilic syndrome   PCM1/JAK2
10q21 t(5;10)(q32;q21) Chronic eosinophilic leukemia/hypereosinophilic syndrome   CCDC6/PDGFRB
12p13 t(5;12)(q31;p13) Chronic eosinophilic leukemia/hypereosinophilic syndrome    
22q11 t(4;22)(q12;q11) Chronic eosinophilic leukemia/hypereosinophilic syndrome   BCR/PDGFRA

Unbalanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
3p21 del(3)(p21) Chronic eosinophilic leukemia/hypereosinophilic syndrome    
4q12 add(4)(q12) Chronic eosinophilic leukemia/hypereosinophilic syndrome    
17q10 i(17)(q10) Chronic eosinophilic leukemia/hypereosinophilic syndrome    
20q11 del(20)(q11q12) Chronic eosinophilic leukemia/hypereosinophilic syndrome    
20q12 del(20)(q11q12) Chronic eosinophilic leukemia/hypereosinophilic syndrome    

Numerical Chromosomal Trisomy Abnormalities

Abnormality Morphology Topography Cases Genes
+8 Chronic eosinophilic leukemia/hypereosinophilic syndrome   10   
+10 Chronic eosinophilic leukemia/hypereosinophilic syndrome    
+15 Chronic eosinophilic leukemia/hypereosinophilic syndrome    
+19 Chronic eosinophilic leukemia/hypereosinophilic syndrome    
+21 Chronic eosinophilic leukemia/hypereosinophilic syndrome    

Numerical Chromosomal Monosomy Abnormalities

Abnormality Morphology Topography Cases Genes
-7 Chronic eosinophilic leukemia/hypereosinophilic syndrome    
-10 Chronic eosinophilic leukemia/hypereosinophilic syndrome    
-13 Chronic eosinophilic leukemia/hypereosinophilic syndrome    
-Y Chronic eosinophilic leukemia/hypereosinophilic syndrome