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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

The Recurrent Chromosome Aberrations in Cancer Database Searcher
  • Brief instructions for searching the database:
    • You must choose one or both of the following two fields: Structural Aberrations and Numerical Aberrations.
    • If you choose Structural Aberrations, you must select at least one of the following fields: Breakpoint, Topography, Morphology, or Gene.
    • If you choose Numerical Aberrations, you must select at least one of the following fields: Chromosome, Topography, Morphology.
    • You may select only one item in each pulldown menu
    • Press Retrieve.
  • A successful search returns a table, with the following headings and entries:
    • Breakpoint, with each entry linked to the OMIM Gene Map (this column is returned only for structural aberrations)
    • Abnormality
    • Morphology, with each entry linked to a similar table that describes all abnormalities with this morphology.
    • Topography, with each entry linked to a similar table that describes all abnormalities at this topography
    • Number of cases, hyperlinked to the list of applicable cases
    • Genes

Aberration type:
Aberration type:




Expand Topography List:

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[Full Text]

Balanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
1q21 t(1;11)(q21;q23) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A+
3q21 inv(3)(q21q26) Acute monoblastic leukemia with differentiation (FAB type M5b)    
3q26 inv(3)(q21q26) Acute monoblastic leukemia with differentiation (FAB type M5b)    
5q35 t(5;11)(q35;p15) Acute monoblastic leukemia with differentiation (FAB type M5b)   NUP98/NSD1
6q27 t(6;11)(q27;q23) Acute monoblastic leukemia with differentiation (FAB type M5b)   15  KMT2A/MLLT4,KMT2A+
7p15 t(7;11)(p15;p15) Acute monoblastic leukemia with differentiation (FAB type M5b)    
8p11 t(8;16)(p11;p13) Acute monoblastic leukemia with differentiation (FAB type M5b)   21  CREBBP+,KAT6A/CREBBP
8q22 t(8;21)(q22;q22) Acute monoblastic leukemia with differentiation (FAB type M5b)   RUNX1/RUNX1T1
9p21 t(9;11)(p21;q23) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A/MLLT3,KMT2A+
9p22 t(9;11)(p22;q23) Acute monoblastic leukemia with differentiation (FAB type M5b)   16   
10p12 ins(11;10)(q23;p12p15) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A/MLLT10
10p12 t(10;11)(p12;q23) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A/ABI1,KMT2A/MLLT10
10p15 ins(11;10)(q23;p12p15) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A/MLLT10
11p15 t(11;20)(p15;q11) Acute monoblastic leukemia with differentiation (FAB type M5b)   NUP98+
11p15 t(5;11)(q35;p15) Acute monoblastic leukemia with differentiation (FAB type M5b)   NUP98/NSD1
11p15 t(7;11)(p15;p15) Acute monoblastic leukemia with differentiation (FAB type M5b)    
11q23 ins(11;10)(q23;p12p15) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A/MLLT10
11q23 t(10;11)(p12;q23) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A/ABI1,KMT2A/MLLT10
11q23 t(11;17)(q23;q21) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A+
11q23 t(11;17)(q23;q25) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A/SEPT9
11q23 t(11;19)(q23;p13) Acute monoblastic leukemia with differentiation (FAB type M5b)   19  KMT2A/ELL,KMT2A/MLLT1,KMT2A/SUGP2
11q23 t(1;11)(q21;q23) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A+
11q23 t(6;11)(q27;q23) Acute monoblastic leukemia with differentiation (FAB type M5b)   15  KMT2A/MLLT4,KMT2A+
11q23 t(9;11)(p21;q23) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A/MLLT3,KMT2A+
11q23 t(9;11)(p22;q23) Acute monoblastic leukemia with differentiation (FAB type M5b)   16   
16p11 t(16;21)(p11;q22) Acute monoblastic leukemia with differentiation (FAB type M5b)   FUS/ERG
16p13 inv(16)(p13q22) Acute monoblastic leukemia with differentiation (FAB type M5b)   CBFB/MYH11
16p13 t(8;16)(p11;p13) Acute monoblastic leukemia with differentiation (FAB type M5b)   21  CREBBP+,KAT6A/CREBBP
16q22 inv(16)(p13q22) Acute monoblastic leukemia with differentiation (FAB type M5b)   CBFB/MYH11
17q21 t(11;17)(q23;q21) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A+
17q25 t(11;17)(q23;q25) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A/SEPT9
19p13 t(11;19)(q23;p13) Acute monoblastic leukemia with differentiation (FAB type M5b)   19  KMT2A/ELL,KMT2A/MLLT1,KMT2A/SUGP2
20q11 t(11;20)(p15;q11) Acute monoblastic leukemia with differentiation (FAB type M5b)   NUP98+
21q22 t(16;21)(p11;q22) Acute monoblastic leukemia with differentiation (FAB type M5b)   FUS/ERG
21q22 t(8;21)(q22;q22) Acute monoblastic leukemia with differentiation (FAB type M5b)   RUNX1/RUNX1T1

Unbalanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
1q10 i(1)(q10) Acute monoblastic leukemia with differentiation (FAB type M5b)    
1q21 del(1)(q21) Acute monoblastic leukemia with differentiation (FAB type M5b)    
3p21 del(3)(p21) Acute monoblastic leukemia with differentiation (FAB type M5b)    
7q32 del(7)(q32) Acute monoblastic leukemia with differentiation (FAB type M5b)    
11q23 add(11)(q23) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A+
11q23 del(11)(q23) Acute monoblastic leukemia with differentiation (FAB type M5b)   KMT2A+
12p11 del(12)(p11p13) Acute monoblastic leukemia with differentiation (FAB type M5b)    
12p13 del(12)(p11p13) Acute monoblastic leukemia with differentiation (FAB type M5b)    
13p11 add(13)(p11) Acute monoblastic leukemia with differentiation (FAB type M5b)    
13q21 del(13)(q21q31) Acute monoblastic leukemia with differentiation (FAB type M5b)    
13q31 del(13)(q21q31) Acute monoblastic leukemia with differentiation (FAB type M5b)    
16p13 add(16)(p13) Acute monoblastic leukemia with differentiation (FAB type M5b)    
17p11 del(17)(p11) Acute monoblastic leukemia with differentiation (FAB type M5b)    
17p13 add(17)(p13) Acute monoblastic leukemia with differentiation (FAB type M5b)    
20q11 del(20)(q11q13) Acute monoblastic leukemia with differentiation (FAB type M5b)    
20q13 del(20)(q11q13) Acute monoblastic leukemia with differentiation (FAB type M5b)    
21q22 add(21)(q22) Acute monoblastic leukemia with differentiation (FAB type M5b)    

Numerical Chromosomal Trisomy Abnormalities

Abnormality Morphology Topography Cases Genes
+2 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+3 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+4 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+5 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+6 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+7 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+8 Acute monoblastic leukemia with differentiation (FAB type M5b)   55   
+10 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+11 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+12 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+13 Acute monoblastic leukemia with differentiation (FAB type M5b)   10   
+15 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+16 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+18 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+19 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+20 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+21 Acute monoblastic leukemia with differentiation (FAB type M5b)    
+22 Acute monoblastic leukemia with differentiation (FAB type M5b)    

Numerical Chromosomal Monosomy Abnormalities

Abnormality Morphology Topography Cases Genes
-3 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-6 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-7 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-10 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-11 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-12 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-13 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-14 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-15 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-16 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-18 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-19 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-20 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-21 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-22 Acute monoblastic leukemia with differentiation (FAB type M5b)    
-Y Acute monoblastic leukemia with differentiation (FAB type M5b)