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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

The Recurrent Chromosome Aberrations in Cancer Database Searcher
  • Brief instructions for searching the database:
    • You must choose one or both of the following two fields: Structural Aberrations and Numerical Aberrations.
    • If you choose Structural Aberrations, you must select at least one of the following fields: Breakpoint, Topography, Morphology, or Gene.
    • If you choose Numerical Aberrations, you must select at least one of the following fields: Chromosome, Topography, Morphology.
    • You may select only one item in each pulldown menu
    • Press Retrieve.
  • A successful search returns a table, with the following headings and entries:
    • Breakpoint, with each entry linked to the OMIM Gene Map (this column is returned only for structural aberrations)
    • Abnormality
    • Morphology, with each entry linked to a similar table that describes all abnormalities with this morphology.
    • Topography, with each entry linked to a similar table that describes all abnormalities at this topography
    • Number of cases, hyperlinked to the list of applicable cases
    • Genes

Aberration type:
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[Full Text]

Balanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
1p32 t(1;11)(p32;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/EPS15,KMT2A+
3q21 inv(3)(q21q26) Acute monoblastic leukemia without differentiation (FAB type M5a)    
3q21 t(3;3)(q21;q26) Acute monoblastic leukemia without differentiation (FAB type M5a)    
3q26 inv(3)(q21q26) Acute monoblastic leukemia without differentiation (FAB type M5a)    
3q26 t(3;3)(q21;q26) Acute monoblastic leukemia without differentiation (FAB type M5a)    
4q21 t(4;11)(q21;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)    
6q27 t(6;11)(q27;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   14  KMT2A/MLLT4,KMT2A+
8p11 inv(8)(p11q13) Acute monoblastic leukemia without differentiation (FAB type M5a)   KAT6A/NCOA2,KAT6A+
8p11 t(8;16)(p11;p13) Acute monoblastic leukemia without differentiation (FAB type M5a)   29  CREBBP+,KAT6A/CREBBP,KAT6A+
8p11 t(8;19)(p11;q13) Acute monoblastic leukemia without differentiation (FAB type M5a)    
8q13 inv(8)(p11q13) Acute monoblastic leukemia without differentiation (FAB type M5a)   KAT6A/NCOA2,KAT6A+
8q22 t(8;21)(q22;q22) Acute monoblastic leukemia without differentiation (FAB type M5a)    
9p21 t(9;11)(p21;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   32  KMT2A/MLLT3,KMT2A+
9p22 t(9;11)(p22;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   45   
9p22 t(9;11)(p22;q24) Acute monoblastic leukemia without differentiation (FAB type M5a)    
10p11 t(10;11)(p11;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A+
10p12 ins(10;11)(p12;q23q13) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/MLLT10
10p12 t(10;11)(p12;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/ABI1,KMT2A/MLLT10,KMT2A+
10p13 t(10;11)(p13;q13) Acute monoblastic leukemia without differentiation (FAB type M5a)    
10p13 t(10;11)(p13;q14) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q13 ins(10;11)(p12;q23q13) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/MLLT10
11q13 t(10;11)(p13;q13) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q14 t(10;11)(p13;q14) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q23 ins(10;11)(p12;q23q13) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/MLLT10
11q23 t(10;11)(p11;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A+
11q23 t(10;11)(p12;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/ABI1,KMT2A/MLLT10,KMT2A+
11q23 t(11;16)(q23;q24) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/USP10
11q23 t(11;17)(q23;q12) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/MLLT6
11q23 t(11;17)(q23;q21) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A+
11q23 t(11;19)(q23;p13) Acute monoblastic leukemia without differentiation (FAB type M5a)   28  KMT2A/MLLT1,KMT2A+
11q23 t(1;11)(p32;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/EPS15,KMT2A+
11q23 t(4;11)(q21;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q23 t(6;11)(q27;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   14  KMT2A/MLLT4,KMT2A+
11q23 t(9;11)(p21;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   32  KMT2A/MLLT3,KMT2A+
11q23 t(9;11)(p22;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   45   
11q24 t(9;11)(p22;q24) Acute monoblastic leukemia without differentiation (FAB type M5a)    
16p11 t(16;21)(p11;q22) Acute monoblastic leukemia without differentiation (FAB type M5a)   FUS/ERG
16p13 inv(16)(p13q22) Acute monoblastic leukemia without differentiation (FAB type M5a)   CBFB/MYH11
16p13 t(8;16)(p11;p13) Acute monoblastic leukemia without differentiation (FAB type M5a)   29  CREBBP+,KAT6A/CREBBP,KAT6A+
16q22 inv(16)(p13q22) Acute monoblastic leukemia without differentiation (FAB type M5a)   CBFB/MYH11
16q24 t(11;16)(q23;q24) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/USP10
17q12 t(11;17)(q23;q12) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/MLLT6
17q21 t(11;17)(q23;q21) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A+
19p13 t(11;19)(q23;p13) Acute monoblastic leukemia without differentiation (FAB type M5a)   28  KMT2A/MLLT1,KMT2A+
19q13 t(8;19)(p11;q13) Acute monoblastic leukemia without differentiation (FAB type M5a)    
21q22 t(16;21)(p11;q22) Acute monoblastic leukemia without differentiation (FAB type M5a)   FUS/ERG
21q22 t(8;21)(q22;q22) Acute monoblastic leukemia without differentiation (FAB type M5a)    

Unbalanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
1p13 del(1)(p13) Acute monoblastic leukemia without differentiation (FAB type M5a)    
1q10 i(1)(q10) Acute monoblastic leukemia without differentiation (FAB type M5a)    
2p23 del(2)(p23) Acute monoblastic leukemia without differentiation (FAB type M5a)    
5p10 i(5)(p10) Acute monoblastic leukemia without differentiation (FAB type M5a)    
5p15 add(5)(p15) Acute monoblastic leukemia without differentiation (FAB type M5a)    
5q13 del(5)(q13q33) Acute monoblastic leukemia without differentiation (FAB type M5a)    
5q15 del(5)(q15q33) Acute monoblastic leukemia without differentiation (FAB type M5a)    
5q33 del(5)(q13q33) Acute monoblastic leukemia without differentiation (FAB type M5a)    
5q33 del(5)(q15q33) Acute monoblastic leukemia without differentiation (FAB type M5a)    
7q22 add(7)(q22) Acute monoblastic leukemia without differentiation (FAB type M5a)    
7q22 del(7)(q22) Acute monoblastic leukemia without differentiation (FAB type M5a)    
7q32 del(7)(q32) Acute monoblastic leukemia without differentiation (FAB type M5a)    
8q10 i(8)(q10) Acute monoblastic leukemia without differentiation (FAB type M5a)    
9q22 del(9)(q22) Acute monoblastic leukemia without differentiation (FAB type M5a)    
10p12 der(10)t(10;11)(p12;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)    
10p12 der(10)t(10;11)(p12;q23)inv(11)(q13q23) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11p15 add(11)(p15) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q13 der(10)t(10;11)(p12;q23)inv(11)(q13q23) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q23 add(11)(q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A+
11q23 del(11)(q23) Acute monoblastic leukemia without differentiation (FAB type M5a)   KMT2A/ARHGEF12
11q23 del(11)(q23q24) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q23 der(10)t(10;11)(p12;q23) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q23 der(10)t(10;11)(p12;q23)inv(11)(q13q23) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q23 der(10)t(10;11)(p12;q23)inv(11)(q13q23) Acute monoblastic leukemia without differentiation (FAB type M5a)    
11q24 del(11)(q23q24) Acute monoblastic leukemia without differentiation (FAB type M5a)    
12q10 der(12;13)(q10;q10) Acute monoblastic leukemia without differentiation (FAB type M5a)    
13p11 add(13)(p11) Acute monoblastic leukemia without differentiation (FAB type M5a)    
13q10 der(12;13)(q10;q10) Acute monoblastic leukemia without differentiation (FAB type M5a)    
13q12 del(13)(q12q22) Acute monoblastic leukemia without differentiation (FAB type M5a)    
13q14 del(13)(q14) Acute monoblastic leukemia without differentiation (FAB type M5a)    
13q22 del(13)(q12q22) Acute monoblastic leukemia without differentiation (FAB type M5a)    
17p13 del(17)(p13) Acute monoblastic leukemia without differentiation (FAB type M5a)    
20q12 del(20)(q12) Acute monoblastic leukemia without differentiation (FAB type M5a)    

Numerical Chromosomal Trisomy Abnormalities

Abnormality Morphology Topography Cases Genes
+1 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+2 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+3 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+4 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+5 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+6 Acute monoblastic leukemia without differentiation (FAB type M5a)   12   
+7 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+8 Acute monoblastic leukemia without differentiation (FAB type M5a)   109   
+9 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+11 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+12 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+13 Acute monoblastic leukemia without differentiation (FAB type M5a)   12   
+14 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+15 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+16 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+18 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+19 Acute monoblastic leukemia without differentiation (FAB type M5a)   19   
+20 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+21 Acute monoblastic leukemia without differentiation (FAB type M5a)   15   
+22 Acute monoblastic leukemia without differentiation (FAB type M5a)    
+X Acute monoblastic leukemia without differentiation (FAB type M5a)    
+Y Acute monoblastic leukemia without differentiation (FAB type M5a)    

Numerical Chromosomal Monosomy Abnormalities

Abnormality Morphology Topography Cases Genes
-2 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-3 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-4 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-5 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-6 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-7 Acute monoblastic leukemia without differentiation (FAB type M5a)   18   
-9 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-10 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-11 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-12 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-13 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-15 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-16 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-17 Acute monoblastic leukemia without differentiation (FAB type M5a)   10   
-18 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-20 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-21 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-22 Acute monoblastic leukemia without differentiation (FAB type M5a)    
-X Acute monoblastic leukemia without differentiation (FAB type M5a)    
-Y Acute monoblastic leukemia without differentiation (FAB type M5a)   14