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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

The Recurrent Chromosome Aberrations in Cancer Database Searcher
  • Brief instructions for searching the database:
    • You must choose one or both of the following two fields: Structural Aberrations and Numerical Aberrations.
    • If you choose Structural Aberrations, you must select at least one of the following fields: Breakpoint, Topography, Morphology, or Gene.
    • If you choose Numerical Aberrations, you must select at least one of the following fields: Chromosome, Topography, Morphology.
    • You may select only one item in each pulldown menu
    • Press Retrieve.
  • A successful search returns a table, with the following headings and entries:
    • Breakpoint, with each entry linked to the OMIM Gene Map (this column is returned only for structural aberrations)
    • Abnormality
    • Morphology, with each entry linked to a similar table that describes all abnormalities with this morphology.
    • Topography, with each entry linked to a similar table that describes all abnormalities at this topography
    • Number of cases, hyperlinked to the list of applicable cases
    • Genes

Aberration type:
Aberration type:




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[Full Text]

Balanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
1p32 t(1;11)(p32;q23) Bilineage or biphenotypic leukemia   KMT2A/EPS15
3q21 inv(3)(q21q26) Bilineage or biphenotypic leukemia    
3q21 t(3;3)(q21;q26) Bilineage or biphenotypic leukemia    
3q26 inv(3)(q21q26) Bilineage or biphenotypic leukemia    
3q26 t(3;3)(q21;q26) Bilineage or biphenotypic leukemia    
4q21 t(4;11)(q21;q23) Bilineage or biphenotypic leukemia   27  KMT2A/AFF1,KMT2A+
6q25 t(6;14)(q25;q32) Bilineage or biphenotypic leukemia    
8p11 t(8;13)(p11;q12) Bilineage or biphenotypic leukemia   ZMYM2/FGFR1
8p21 t(8;14)(p21;q32) Bilineage or biphenotypic leukemia    
8q22 t(8;21)(q22;q22) Bilineage or biphenotypic leukemia   10   
8q24 t(8;14)(q24;q32) Bilineage or biphenotypic leukemia    
9p12 inv(9)(p12q13) Bilineage or biphenotypic leukemia    
9p21 t(9;11)(p21;q23) Bilineage or biphenotypic leukemia   KMT2A+
9p22 t(9;11)(p22;q23) Bilineage or biphenotypic leukemia    
9q13 inv(9)(p12q13) Bilineage or biphenotypic leukemia    
9q34 t(9;22)(q34;q11) Bilineage or biphenotypic leukemia   91  BCR/ABL1
11q23 t(11;19)(q23;p13) Bilineage or biphenotypic leukemia   17  KMT2A/ELL,KMT2A/MLLT1
11q23 t(1;11)(p32;q23) Bilineage or biphenotypic leukemia   KMT2A/EPS15
11q23 t(4;11)(q21;q23) Bilineage or biphenotypic leukemia   27  KMT2A/AFF1,KMT2A+
11q23 t(9;11)(p21;q23) Bilineage or biphenotypic leukemia   KMT2A+
11q23 t(9;11)(p22;q23) Bilineage or biphenotypic leukemia    
12p13 t(12;19)(p13;p13) Bilineage or biphenotypic leukemia    
12p13 t(12;22)(p13;q12) Bilineage or biphenotypic leukemia    
12p13 t(X;12)(p11;p13) Bilineage or biphenotypic leukemia    
13q12 t(8;13)(p11;q12) Bilineage or biphenotypic leukemia   ZMYM2/FGFR1
14q32 t(6;14)(q25;q32) Bilineage or biphenotypic leukemia    
14q32 t(8;14)(p21;q32) Bilineage or biphenotypic leukemia    
14q32 t(8;14)(q24;q32) Bilineage or biphenotypic leukemia    
15q22 t(15;17)(q22;q21) Bilineage or biphenotypic leukemia   PML/RARA
16p13 inv(16)(p13q22) Bilineage or biphenotypic leukemia    
16q22 inv(16)(p13q22) Bilineage or biphenotypic leukemia    
17q21 t(15;17)(q22;q21) Bilineage or biphenotypic leukemia   PML/RARA
19p13 t(11;19)(q23;p13) Bilineage or biphenotypic leukemia   17  KMT2A/ELL,KMT2A/MLLT1
19p13 t(12;19)(p13;p13) Bilineage or biphenotypic leukemia    
21q22 t(8;21)(q22;q22) Bilineage or biphenotypic leukemia   10   
22q11 t(9;22)(q34;q11) Bilineage or biphenotypic leukemia   91  BCR/ABL1
22q12 t(12;22)(p13;q12) Bilineage or biphenotypic leukemia    
Xp11 t(X;12)(p11;p13) Bilineage or biphenotypic leukemia    

Unbalanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
1p36 add(1)(p36) Bilineage or biphenotypic leukemia    
1q21 der(11)t(1;11)(q21;q23) Bilineage or biphenotypic leukemia    
1q21 dup(1)(q21q32) Bilineage or biphenotypic leukemia    
1q23 der(19)t(1;19)(q23;p13) Bilineage or biphenotypic leukemia    
1q32 dup(1)(q21q32) Bilineage or biphenotypic leukemia    
2p11 add(2)(p11) Bilineage or biphenotypic leukemia    
3q11 del(3)(q11) Bilineage or biphenotypic leukemia    
5q22 del(5)(q22) Bilineage or biphenotypic leukemia    
5q23 del(5)(q23q32) Bilineage or biphenotypic leukemia    
5q23 del(5)(q23q33) Bilineage or biphenotypic leukemia    
5q32 del(5)(q23q32) Bilineage or biphenotypic leukemia    
5q33 del(5)(q23q33) Bilineage or biphenotypic leukemia    
6p25 add(6)(p25) Bilineage or biphenotypic leukemia    
6q21 del(6)(q21) Bilineage or biphenotypic leukemia    
6q22 del(6)(q22) Bilineage or biphenotypic leukemia    
6q23 del(6)(q23q25) Bilineage or biphenotypic leukemia    
6q25 del(6)(q23q25) Bilineage or biphenotypic leukemia    
7p11 del(7)(p11) Bilineage or biphenotypic leukemia    
7q22 del(7)(q22) Bilineage or biphenotypic leukemia    
8p21 del(8)(p21) Bilineage or biphenotypic leukemia    
8q10 i(8)(q10) Bilineage or biphenotypic leukemia    
9p11 add(9)(p11) Bilineage or biphenotypic leukemia    
9p12 del(9)(p12) Bilineage or biphenotypic leukemia    
9q13 del(9)(q13q22) Bilineage or biphenotypic leukemia    
9q22 del(9)(q13q22) Bilineage or biphenotypic leukemia    
9q22 del(9)(q22) Bilineage or biphenotypic leukemia    
11q14 del(11)(q14) Bilineage or biphenotypic leukemia    
11q23 del(11)(q23) Bilineage or biphenotypic leukemia    
11q23 der(11)t(1;11)(q21;q23) Bilineage or biphenotypic leukemia    
12p11 del(12)(p11) Bilineage or biphenotypic leukemia    
12p11 del(12)(p11p12) Bilineage or biphenotypic leukemia    
12p11 del(12)(p11p13) Bilineage or biphenotypic leukemia    
12p12 del(12)(p11p12) Bilineage or biphenotypic leukemia    
12p12 del(12)(p12) Bilineage or biphenotypic leukemia    
12p13 add(12)(p13) Bilineage or biphenotypic leukemia    
12p13 del(12)(p11p13) Bilineage or biphenotypic leukemia    
13q10 der(13;14)(q10;q10) Bilineage or biphenotypic leukemia    
13q12 del(13)(q12) Bilineage or biphenotypic leukemia    
13q12 del(13)(q12q14) Bilineage or biphenotypic leukemia    
13q14 del(13)(q12q14) Bilineage or biphenotypic leukemia    
13q14 del(13)(q14q32) Bilineage or biphenotypic leukemia    
13q32 del(13)(q14q32) Bilineage or biphenotypic leukemia    
14q10 der(13;14)(q10;q10) Bilineage or biphenotypic leukemia    
14q22 add(14)(q22) Bilineage or biphenotypic leukemia    
14q24 add(14)(q24) Bilineage or biphenotypic leukemia    
14q32 add(14)(q32) Bilineage or biphenotypic leukemia    
15q22 add(15)(q22) Bilineage or biphenotypic leukemia    
16p13 add(16)(p13) Bilineage or biphenotypic leukemia    
17p13 add(17)(p13) Bilineage or biphenotypic leukemia    
17q10 i(17)(q10) Bilineage or biphenotypic leukemia    
19p13 add(19)(p13) Bilineage or biphenotypic leukemia    
19p13 der(19)t(1;19)(q23;p13) Bilineage or biphenotypic leukemia    
19q13 add(19)(q13) Bilineage or biphenotypic leukemia    
20q11 del(20)(q11) Bilineage or biphenotypic leukemia    
21q10 i(21)(q10) Bilineage or biphenotypic leukemia    
21q22 add(21)(q22) Bilineage or biphenotypic leukemia    

Numerical Chromosomal Trisomy Abnormalities

Abnormality Morphology Topography Cases Genes
+1 Bilineage or biphenotypic leukemia   10   
+2 Bilineage or biphenotypic leukemia    
+3 Bilineage or biphenotypic leukemia    
+4 Bilineage or biphenotypic leukemia   21   
+5 Bilineage or biphenotypic leukemia    
+6 Bilineage or biphenotypic leukemia   20   
+7 Bilineage or biphenotypic leukemia    
+8 Bilineage or biphenotypic leukemia   34   
+9 Bilineage or biphenotypic leukemia    
+10 Bilineage or biphenotypic leukemia   10   
+11 Bilineage or biphenotypic leukemia    
+12 Bilineage or biphenotypic leukemia    
+13 Bilineage or biphenotypic leukemia   13   
+14 Bilineage or biphenotypic leukemia    
+15 Bilineage or biphenotypic leukemia    
+17 Bilineage or biphenotypic leukemia    
+18 Bilineage or biphenotypic leukemia   10   
+19 Bilineage or biphenotypic leukemia   21   
+20 Bilineage or biphenotypic leukemia    
+21 Bilineage or biphenotypic leukemia   32   
+22 Bilineage or biphenotypic leukemia   11   
+X Bilineage or biphenotypic leukemia   12   
+Y Bilineage or biphenotypic leukemia    

Numerical Chromosomal Monosomy Abnormalities

Abnormality Morphology Topography Cases Genes
-1 Bilineage or biphenotypic leukemia    
-2 Bilineage or biphenotypic leukemia    
-3 Bilineage or biphenotypic leukemia    
-4 Bilineage or biphenotypic leukemia    
-5 Bilineage or biphenotypic leukemia   11   
-6 Bilineage or biphenotypic leukemia    
-7 Bilineage or biphenotypic leukemia   50   
-8 Bilineage or biphenotypic leukemia    
-9 Bilineage or biphenotypic leukemia    
-10 Bilineage or biphenotypic leukemia    
-11 Bilineage or biphenotypic leukemia    
-12 Bilineage or biphenotypic leukemia   11   
-13 Bilineage or biphenotypic leukemia   13   
-14 Bilineage or biphenotypic leukemia    
-15 Bilineage or biphenotypic leukemia    
-16 Bilineage or biphenotypic leukemia    
-17 Bilineage or biphenotypic leukemia   14   
-18 Bilineage or biphenotypic leukemia    
-19 Bilineage or biphenotypic leukemia    
-20 Bilineage or biphenotypic leukemia    
-21 Bilineage or biphenotypic leukemia    
-22 Bilineage or biphenotypic leukemia    
-X Bilineage or biphenotypic leukemia   12   
-Y Bilineage or biphenotypic leukemia