Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Chromosomes
  • Tools
  • Genetic and Physical SNP Maps
  • SNP500Cancer
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

The Recurrent Chromosome Aberrations in Cancer Database Searcher
  • Brief instructions for searching the database:
    • You must choose one or both of the following two fields: Structural Aberrations and Numerical Aberrations.
    • If you choose Structural Aberrations, you must select at least one of the following fields: Breakpoint, Topography, Morphology, or Gene.
    • If you choose Numerical Aberrations, you must select at least one of the following fields: Chromosome, Topography, Morphology.
    • You may select only one item in each pulldown menu
    • Press Retrieve.
  • A successful search returns a table, with the following headings and entries:
    • Breakpoint, with each entry linked to the OMIM Gene Map (this column is returned only for structural aberrations)
    • Abnormality
    • Morphology, with each entry linked to a similar table that describes all abnormalities with this morphology.
    • Topography, with each entry linked to a similar table that describes all abnormalities at this topography
    • Number of cases, hyperlinked to the list of applicable cases
    • Genes

Aberration type:
Aberration type:




Expand Topography List:

Expand Morphology List:

Expand Gene List:




[Full Text]

Balanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
1p22 inv(1)(p22p36) Adenocarcinoma Breast  
1p22 inv(1)(p22q21) Diffuse large B-cell lymphoma    
1p22 t(1;10)(p22;q24) Myxoinflammatory fibroblastic sarcoma Soft tissue MGEA5+,TGFBR3+
1p22 t(1;12)(p22;p13) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
1p22 t(1;14)(p22;q32) Diffuse large B-cell lymphoma    
1p22 t(1;14)(p22;q32) Extranodal marginal zone B-cell lymphoma Lung IGH+
1p22 t(1;14)(p22;q32) Extranodal marginal zone B-cell lymphoma Unknown site IGH/BCL10
1p22 t(1;2)(p22;q21) Squamous cell carcinoma Larynx  
1p22 t(1;2)(p22;q31) Synovial sarcoma Soft tissue  
1p22 t(1;21)(p22;q22) Acute myeloblastic leukemia with maturation (FAB type M2)   RUNX1/CLCA2,RUNX1+
1p22 t(1;9;22)(p22;q34;q11) Chronic myeloid leukemia, aberrant translocation   BCR+

Unbalanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
1p22 add(1)(p22) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
1p22 add(1)(p22) Acute myeloblastic leukemia with maturation (FAB type M2)    
1p22 add(1)(p22) Acute myeloid leukemia, NOS    
1p22 add(1)(p22) Adenocarcinoma Breast  
1p22 add(1)(p22) Adenocarcinoma Lung  
1p22 add(1)(p22) Adenocarcinoma Ovary  
1p22 add(1)(p22) Chronic myeloid leukemia, t(9;22)    
1p22 add(1)(p22) Diffuse large B-cell lymphoma    
1p22 add(1)(p22) Follicular lymphoma    
1p22 add(1)(p22) Leiomyosarcoma Soft tissue  
1p22 add(1)(p22) Mantle cell lymphoma    
1p22 add(1)(p22) Mature B-cell neoplasm, NOS    
1p22 add(1)(p22) Mesothelioma Pleura  
1p22 add(1)(p22) Multiple myeloma   11   
1p22 add(1)(p22) Neuroblastoma Soft tissue  
1p22 add(1)(p22) Neuroblastoma Adrenal  
1p22 add(1)(p22) Neuroblastoma Intraabdominal  
1p22 add(1)(p22) Neuroglial neoplasm, special type Brain  
1p22 add(1)(p22) Seminoma/Dysgerminoma Testis  
1p22 add(1)(p22) Squamous cell carcinoma Lung  
1p22 add(1)(p22) Teratoma (mature and immature) Testis  
1p22 del(1)(p11p22) Multiple myeloma   15   
1p22 del(1)(p12p22) Acute myeloblastic leukemia with maturation (FAB type M2)    
1p22 del(1)(p12p22) Mantle cell lymphoma    
1p22 del(1)(p12p22) Multiple myeloma    
1p22 del(1)(p13p22) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
1p22 del(1)(p13p22) Diffuse large B-cell lymphoma    
1p22 del(1)(p13p22) Mantle cell lymphoma    
1p22 del(1)(p13p22) Multiple myeloma   13   
1p22 del(1)(p21p22) Multiple myeloma    
1p22 del(1)(p22) Acute erythroleukemia (FAB type M6)    
1p22 del(1)(p22) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
1p22 del(1)(p22) Acute monoblastic leukemia (FAB type M5)    
1p22 del(1)(p22) Acute myeloblastic leukemia without maturation (FAB type M1)    
1p22 del(1)(p22) Acute myeloid leukemia, NOS   13   
1p22 del(1)(p22) Adenocarcinoma Kidney  
1p22 del(1)(p22) Adenocarcinoma Breast 21   
1p22 del(1)(p22) Adenocarcinoma Ovary  
1p22 del(1)(p22) Adenocarcinoma Liver  
1p22 del(1)(p22) Adenocarcinoma Large intestine  
1p22 del(1)(p22) Adenocarcinoma Oesophagus  
1p22 del(1)(p22) Adenocarcinoma Stomach  
1p22 del(1)(p22) Adenocarcinoma Lung  
1p22 del(1)(p22) Astrocytoma, grade I-II Brain  
1p22 del(1)(p22) Astrocytoma, grade III-IV/Glioblastoma Brain  
1p22 del(1)(p22) Burkitt lymphoma/leukemia    
1p22 del(1)(p22) Carcinoma, NOS Breast  
1p22 del(1)(p22) Chronic myeloid leukemia, t(9;22)    
1p22 del(1)(p22) Diffuse large B-cell lymphoma   10   
1p22 del(1)(p22) Follicular lymphoma    
1p22 del(1)(p22) Gastrointestinal stromal tumor Small intestine  
1p22 del(1)(p22) Hepatoblastoma Liver  
1p22 del(1)(p22) Leiomyoma Uterus, corpus  
1p22 del(1)(p22) Liposarcoma, pleomorphic Soft tissue  
1p22 del(1)(p22) Malignant melanoma Eye  
1p22 del(1)(p22) Malignant melanoma Skin  
1p22 del(1)(p22) Malignant melanoma Unknown site  
1p22 del(1)(p22) Mature B-cell neoplasm, NOS    
1p22 del(1)(p22) Meningioma Brain  
1p22 del(1)(p22) Mesothelioma Pleura  
1p22 del(1)(p22) Multiple myeloma    
1p22 del(1)(p22) Neuroblastoma Adrenal  
1p22 del(1)(p22) Neuroblastoma Soft tissue  
1p22 del(1)(p22) Refractory anemia with excess blasts-2    
1p22 del(1)(p22) Refractory anemia with excess of blasts (FAB)    
1p22 del(1)(p22) Squamous cell carcinoma Larynx  
1p22 del(1)(p22) Squamous cell carcinoma Lung  
1p22 del(1)(p22) Squamous cell carcinoma Tongue  
1p22 del(1)(p22) Squamous cell carcinoma Oral cavity  
1p22 del(1)(p22) Synovial sarcoma Soft tissue  
1p22 del(1)(p22) Teratoma (mature and immature) Testis  
1p22 del(1)(p22) Teratoma (mature and immature) Intraabdominal  
1p22 del(1)(p22) Transitional cell carcinoma Bladder  
1p22 del(1)(p22) Undifferentiated carcinoma, large cell Lung  
1p22 del(1)(p22) Wilms tumor Kidney  
1p22 del(1)(p22p31) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
1p22 del(1)(p22p31) Mantle cell lymphoma    
1p22 del(1)(p22p31) Multiple myeloma    
1p22 del(1)(p22p32) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
1p22 del(1)(p22p32) Diffuse large B-cell lymphoma    
1p22 del(1)(p22p32) Mantle cell lymphoma    
1p22 del(1)(p22p32) Multiple myeloma   10   
1p22 del(1)(p22p33) Multiple myeloma    
1p22 del(1)(p22p35) Multiple myeloma    
1p22 del(1)(p22p36) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
1p22 del(1)(p22p36) Acute myeloid leukemia, NOS    
1p22 del(1)(p22p36) Mature B-cell neoplasm, NOS    
1p22 del(1)(p22p36) Multiple myeloma    
1p22 der(10)t(1;10)(p22;q24) Myxoinflammatory fibroblastic sarcoma Soft tissue  
1p22 dup(1)(p22p36) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
1p22 dup(1)(p22p36) Follicular lymphoma