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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

The Recurrent Chromosome Aberrations in Cancer Database Searcher
  • Brief instructions for searching the database:
    • You must choose one or both of the following two fields: Structural Aberrations and Numerical Aberrations.
    • If you choose Structural Aberrations, you must select at least one of the following fields: Breakpoint, Topography, Morphology, or Gene.
    • If you choose Numerical Aberrations, you must select at least one of the following fields: Chromosome, Topography, Morphology.
    • You may select only one item in each pulldown menu
    • Press Retrieve.
  • A successful search returns a table, with the following headings and entries:
    • Breakpoint, with each entry linked to the OMIM Gene Map (this column is returned only for structural aberrations)
    • Abnormality
    • Morphology, with each entry linked to a similar table that describes all abnormalities with this morphology.
    • Topography, with each entry linked to a similar table that describes all abnormalities at this topography
    • Number of cases, hyperlinked to the list of applicable cases
    • Genes

Aberration type:
Aberration type:




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[Full Text]

Balanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
16q22 ins(16)(q22p13p13) Acute myelomonocytic leukemia (FAB type M4)   CBFB/MYH11
16q22 inv(16)(p13q22) Acute erythroleukemia (FAB type M6)    
16q22 inv(16)(p13q22) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
16q22 inv(16)(p13q22) Acute megakaryoblastic leukemia (FAB type M7)    
16q22 inv(16)(p13q22) Acute monoblastic leukemia (FAB type M5)   13  CBFB/MYH11
16q22 inv(16)(p13q22) Acute monoblastic leukemia with differentiation (FAB type M5b)   CBFB/MYH11
16q22 inv(16)(p13q22) Acute monoblastic leukemia without differentiation (FAB type M5a)   CBFB/MYH11
16q22 inv(16)(p13q22) Acute myeloblastic leukemia with maturation (FAB type M2)   75  CBFB/MYH11
16q22 inv(16)(p13q22) Acute myeloblastic leukemia with minimal differentiation (FAB type M0)   CBFB/MYH11
16q22 inv(16)(p13q22) Acute myeloblastic leukemia without maturation (FAB type M1)   30  CBFB/MYH11
16q22 inv(16)(p13q22) Acute myeloid leukemia, NOS   144  CBFB/MYH11
16q22 inv(16)(p13q22) Acute myelomonocytic leukemia (FAB type M4)   654  CBFB/MYH11,MYH11+
16q22 inv(16)(p13q22) Acute promyelocytic leukemia (FAB type M3)    
16q22 inv(16)(p13q22) Adenocarcinoma Large intestine  
16q22 inv(16)(p13q22) Bilineage or biphenotypic leukemia    
16q22 inv(16)(p13q22) Chronic myeloid leukemia, t(9;22)   19  CBFB/MYH11
16q22 inv(16)(p13q22) Myelodysplastic syndrome, NOS   CBFB/MYH11
16q22 inv(16)(p13q22) Refractory anemia with excess blasts-2    
16q22 inv(16)(p13q22) Refractory anemia with ringed sideroblasts   CBFB/MYH11
16q22 t(13;16)(q12;q22) Wilms tumor Kidney  
16q22 t(14;16)(q32;q22) Multiple myeloma    
16q22 t(16;16)(p13;q22) Acute myeloblastic leukemia with maturation (FAB type M2)   CBFB/MYH11,MYH11/CBFB
16q22 t(16;16)(p13;q22) Acute myeloblastic leukemia without maturation (FAB type M1)   CBFB/MYH11,MYH11/CBFB
16q22 t(16;16)(p13;q22) Acute myelomonocytic leukemia (FAB type M4)   38  CBFB/MYH11,MYH11/CBFB
16q22 t(16;17)(q22;p13) Aneurysmal bone cyst Skeleton  
16q22 t(16;17)(q22;q11) Acute erythroleukemia (FAB type M6)    
16q22 t(9;22;16)(q34;q11;q22) Chronic myeloid leukemia, aberrant translocation    

Unbalanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
16q22 add(16)(q22) Acute erythroleukemia (FAB type M6)    
16q22 add(16)(q22) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
16q22 add(16)(q22) Acute myeloid leukemia, NOS    
16q22 add(16)(q22) Acute myelomonocytic leukemia (FAB type M4)    
16q22 add(16)(q22) Adenocarcinoma Lung  
16q22 add(16)(q22) Adenocarcinoma Breast  
16q22 add(16)(q22) Anaplastic large cell lymphoma, systemic type    
16q22 add(16)(q22) Combined germ cell tumors Testis  
16q22 add(16)(q22) Diffuse large B-cell lymphoma    
16q22 add(16)(q22) Follicular lymphoma    
16q22 add(16)(q22) Hodgkin disease, nodular sclerosis    
16q22 add(16)(q22) Mesothelioma Pleura  
16q22 add(16)(q22) Multiple myeloma    
16q22 add(16)(q22) Mycosis fungoides/Sezary syndrome    
16q22 add(16)(q22) Myelodysplastic syndrome, NOS    
16q22 add(16)(q22) Plasma cell leukemia    
16q22 add(16)(q22) Squamous cell carcinoma Oro- and hypopharynx  
16q22 add(16)(q22) Teratoma (mature and immature) Testis  
16q22 add(16)(q22) Undifferentiated carcinoma, large cell Lung  
16q22 del(16)(q12q22) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
16q22 del(16)(q22) Acute erythroleukemia (FAB type M6)    
16q22 del(16)(q22) Acute lymphoblastic leukemia/lymphoblastic lymphoma   15  CTCF/PARD6A
16q22 del(16)(q22) Acute monoblastic leukemia (FAB type M5)    
16q22 del(16)(q22) Acute myeloblastic leukemia with maturation (FAB type M2)   14   
16q22 del(16)(q22) Acute myeloblastic leukemia without maturation (FAB type M1)    
16q22 del(16)(q22) Acute myeloid leukemia, NOS   15   
16q22 del(16)(q22) Acute myelomonocytic leukemia (FAB type M4)   25   
16q22 del(16)(q22) Acute promyelocytic leukemia (FAB type M3)    
16q22 del(16)(q22) Adenocarcinoma Kidney  
16q22 del(16)(q22) Adenocarcinoma Ovary  
16q22 del(16)(q22) Adenocarcinoma Pancreas  
16q22 del(16)(q22) Adenocarcinoma Breast  
16q22 del(16)(q22) Adenocarcinoma Prostate  
16q22 del(16)(q22) Alveolar rhabdomyosarcoma Soft tissue  
16q22 del(16)(q22) Aneurysmal bone cyst Skeleton  
16q22 del(16)(q22) Astrocytoma, grade III-IV/Glioblastoma Brain  
16q22 del(16)(q22) Chronic lymphocytic leukemia    
16q22 del(16)(q22) Chronic myeloid leukemia, aberrant translocation    
16q22 del(16)(q22) Chronic myeloid leukemia, t(9;22)    
16q22 del(16)(q22) Diffuse large B-cell lymphoma    
16q22 del(16)(q22) Endometrial stromal sarcoma Uterus, corpus  
16q22 del(16)(q22) Follicular lymphoma    
16q22 del(16)(q22) Hepatosplenic T-cell lymphoma    
16q22 del(16)(q22) Malignant melanoma Eye  
16q22 del(16)(q22) Mantle cell lymphoma    
16q22 del(16)(q22) Mature T- and NK-cell neoplasm, NOS    
16q22 del(16)(q22) Monoclonal gammopathy of undetermined significance    
16q22 del(16)(q22) Multiple myeloma   21   
16q22 del(16)(q22) Myelodysplastic syndrome, NOS    
16q22 del(16)(q22) Oligodendroglioma Brain  
16q22 del(16)(q22) Plasma cell leukemia    
16q22 del(16)(q22) Refractory anemia    
16q22 del(16)(q22) Refractory anemia with excess of blasts (FAB)    
16q22 del(16)(q22) Retinoblastoma Eye  
16q22 del(16)(q22) Squamous cell carcinoma Oral cavity  
16q22 del(16)(q22) Squamous cell carcinoma Larynx  
16q22 del(16)(q22) Squamous cell carcinoma Tongue  
16q22 del(16)(q22) Squamous cell carcinoma Oro- and hypopharynx  
16q22 del(16)(q22) Synovial sarcoma Soft tissue  
16q22 del(16)(q22) Wilms tumor Kidney  
16q22 del(16)(q22q22) Acute lymphoblastic leukemia/lymphoblastic lymphoma   CTCF/PARD6A
16q22 del(16)(q22q22) Acute lymphoblastic leukemia/lymphoblastic lymphoma   CTCF/PARD6A
16q22 del(16)(q22q22) Multiple myeloma    
16q22 del(16)(q22q22) Multiple myeloma    
16q22 del(16)(q22q24) Acute monoblastic leukemia (FAB type M5)    
16q22 del(16)(q22q24) Acute myeloid leukemia, NOS    
16q22 der(16)inv(16)(p13q22)t(10;16) Acute myelomonocytic leukemia (FAB type M4)    
16q22 der(16)inv(16)(p13q22)t(1;16) Acute myelomonocytic leukemia (FAB type M4)    
16q22 der(16)t(10;16)inv(16)(p13q22) Acute myelomonocytic leukemia (FAB type M4)    
16q22 der(16)t(12;16)(p13;q22) Acute myeloid leukemia, NOS    
16q22 der(16)t(1;16)(q10;q22) Multiple myeloma    
16q22 der(16)t(1;16)(q31;q22) Diffuse large B-cell lymphoma