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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

The Recurrent Chromosome Aberrations in Cancer Database Searcher
  • Brief instructions for searching the database:
    • You must choose one or both of the following two fields: Structural Aberrations and Numerical Aberrations.
    • If you choose Structural Aberrations, you must select at least one of the following fields: Breakpoint, Topography, Morphology, or Gene.
    • If you choose Numerical Aberrations, you must select at least one of the following fields: Chromosome, Topography, Morphology.
    • You may select only one item in each pulldown menu
    • Press Retrieve.
  • A successful search returns a table, with the following headings and entries:
    • Breakpoint, with each entry linked to the OMIM Gene Map (this column is returned only for structural aberrations)
    • Abnormality
    • Morphology, with each entry linked to a similar table that describes all abnormalities with this morphology.
    • Topography, with each entry linked to a similar table that describes all abnormalities at this topography
    • Number of cases, hyperlinked to the list of applicable cases
    • Genes

Aberration type:
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[Full Text]

Balanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
16p13 ins(16)(q22p13p13) Acute myelomonocytic leukemia (FAB type M4)   CBFB/MYH11
16p13 ins(16)(q22p13p13) Acute myelomonocytic leukemia (FAB type M4)   CBFB/MYH11
16p13 inv(16)(p13q13) Acute myelomonocytic leukemia (FAB type M4)    
16p13 inv(16)(p13q22) Acute erythroleukemia (FAB type M6)    
16p13 inv(16)(p13q22) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
16p13 inv(16)(p13q22) Acute megakaryoblastic leukemia (FAB type M7)    
16p13 inv(16)(p13q22) Acute monoblastic leukemia (FAB type M5)   13  CBFB/MYH11
16p13 inv(16)(p13q22) Acute monoblastic leukemia with differentiation (FAB type M5b)   CBFB/MYH11
16p13 inv(16)(p13q22) Acute monoblastic leukemia without differentiation (FAB type M5a)   CBFB/MYH11
16p13 inv(16)(p13q22) Acute myeloblastic leukemia with maturation (FAB type M2)   75  CBFB/MYH11
16p13 inv(16)(p13q22) Acute myeloblastic leukemia with minimal differentiation (FAB type M0)   CBFB/MYH11
16p13 inv(16)(p13q22) Acute myeloblastic leukemia without maturation (FAB type M1)   30  CBFB/MYH11
16p13 inv(16)(p13q22) Acute myeloid leukemia, NOS   144  CBFB/MYH11
16p13 inv(16)(p13q22) Acute myelomonocytic leukemia (FAB type M4)   654  CBFB/MYH11,MYH11+
16p13 inv(16)(p13q22) Acute promyelocytic leukemia (FAB type M3)    
16p13 inv(16)(p13q22) Adenocarcinoma Large intestine  
16p13 inv(16)(p13q22) Bilineage or biphenotypic leukemia    
16p13 inv(16)(p13q22) Chronic myeloid leukemia, t(9;22)   19  CBFB/MYH11
16p13 inv(16)(p13q22) Myelodysplastic syndrome, NOS   CBFB/MYH11
16p13 inv(16)(p13q22) Refractory anemia with excess blasts-2    
16p13 inv(16)(p13q22) Refractory anemia with ringed sideroblasts   CBFB/MYH11
16p13 inv(16)(p13q24) Acute megakaryoblastic leukemia (FAB type M7)   CBFA2T3/GLIS2
16p13 t(11;16)(q13;p13) Chondroid lipoma Soft tissue C11ORF95/MKL2
16p13 t(11;16)(q23;p13) Acute lymphoblastic leukemia/lymphoblastic lymphoma   KMT2A/CREBBP,KMT2A+
16p13 t(11;16)(q23;p13) Acute monoblastic leukemia (FAB type M5)    
16p13 t(11;16)(q23;p13) Acute myeloid leukemia, NOS   KMT2A/CREBBP,KMT2A/MYH11,KMT2A+
16p13 t(11;16)(q23;p13) Acute myelomonocytic leukemia (FAB type M4)   KMT2A/CREBBP
16p13 t(11;16)(q23;p13) Chronic myelomonocytic leukemia   KMT2A/CREBBP
16p13 t(11;16)(q23;p13) Myelodysplastic syndrome, NOS   KMT2A/CREBBP
16p13 t(16;16)(p13;q22) Acute myeloblastic leukemia with maturation (FAB type M2)   CBFB/MYH11,MYH11/CBFB
16p13 t(16;16)(p13;q22) Acute myeloblastic leukemia without maturation (FAB type M1)   CBFB/MYH11,MYH11/CBFB
16p13 t(16;16)(p13;q22) Acute myelomonocytic leukemia (FAB type M4)   38  CBFB/MYH11,MYH11/CBFB
16p13 t(16;20)(p13;q13) Multiple myeloma    
16p13 t(16;22)(p13;q11) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
16p13 t(16;22)(p13;q11) Chronic myeloid leukemia, aberrant translocation    
16p13 t(1;16)(q23;p13) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
16p13 t(3;16)(q27;p13) Diffuse large B-cell lymphoma   BCL6/CIITA,BCL6+,CIITA/BCL6
16p13 t(8;16)(p11;p13) Acute monoblastic leukemia (FAB type M5)   27  CREBBP/KAT6A,CREBBP+,KAT6A/CREBBP,KAT6A+
16p13 t(8;16)(p11;p13) Acute monoblastic leukemia with differentiation (FAB type M5b)   21  CREBBP+,KAT6A/CREBBP
16p13 t(8;16)(p11;p13) Acute monoblastic leukemia without differentiation (FAB type M5a)   29  CREBBP+,KAT6A/CREBBP,KAT6A+
16p13 t(8;16)(p11;p13) Acute myeloblastic leukemia with maturation (FAB type M2)   KAT6A/CREBBP
16p13 t(8;16)(p11;p13) Acute myeloid leukemia, NOS   13  KAT6A/CREBBP
16p13 t(8;16)(p11;p13) Acute myelomonocytic leukemia (FAB type M4)   29  CREBBP+,KAT6A/CREBBP,KAT6A+
16p13 t(9;16)(q22;p13) Basal cell carcinoma Skin  
16p13 t(9;22;16)(q34;q11;p13) Chronic myeloid leukemia, aberrant translocation   BCR/ABL1

Unbalanced Chromosomal Abnormalities

Band Abnormality Morphology Topography Cases Genes
16p13 add(16)(p13) Acute erythroleukemia (FAB type M6)    
16p13 add(16)(p13) Acute lymphoblastic leukemia/lymphoblastic lymphoma   21   
16p13 add(16)(p13) Acute megakaryoblastic leukemia (FAB type M7)    
16p13 add(16)(p13) Acute monoblastic leukemia with differentiation (FAB type M5b)    
16p13 add(16)(p13) Acute myeloblastic leukemia with maturation (FAB type M2)    
16p13 add(16)(p13) Acute myeloblastic leukemia without maturation (FAB type M1)    
16p13 add(16)(p13) Acute myeloid leukemia, NOS   21   
16p13 add(16)(p13) Acute myelomonocytic leukemia (FAB type M4)    
16p13 add(16)(p13) Acute promyelocytic leukemia (FAB type M3)    
16p13 add(16)(p13) Adenocarcinoma Ovary  
16p13 add(16)(p13) Adenocarcinoma Breast  
16p13 add(16)(p13) Adenocarcinoma Uterus, corpus  
16p13 add(16)(p13) Adenocarcinoma Kidney  
16p13 add(16)(p13) Adenocarcinoma Large intestine  
16p13 add(16)(p13) Adenocarcinoma Pancreas  
16p13 add(16)(p13) Adenocarcinoma Lung  
16p13 add(16)(p13) Adult T-cell lymphoma/leukemia (HTLV-1+)    
16p13 add(16)(p13) Anaplastic large cell lymphoma, systemic type    
16p13 add(16)(p13) Astrocytoma, grade III-IV/Glioblastoma Brain  
16p13 add(16)(p13) B-prolymphocytic leukemia    
16p13 add(16)(p13) Bilineage or biphenotypic leukemia    
16p13 add(16)(p13) Burkitt lymphoma/leukemia    
16p13 add(16)(p13) Chronic lymphocytic leukemia    
16p13 add(16)(p13) Diffuse large B-cell lymphoma   15   
16p13 add(16)(p13) Follicular lymphoma   11   
16p13 add(16)(p13) Leiomyosarcoma Soft tissue  
16p13 add(16)(p13) Leiomyosarcoma Large intestine  
16p13 add(16)(p13) Malignant epithelial tumor, special type Ovary  
16p13 add(16)(p13) Malignant melanoma Unknown site  
16p13 add(16)(p13) Malignant peripheral nerve sheath tumor/Triton Soft tissue  
16p13 add(16)(p13) Mantle cell lymphoma    
16p13 add(16)(p13) Mature B-cell neoplasm, NOS    
16p13 add(16)(p13) Multiple myeloma   15   
16p13 add(16)(p13) Mycosis fungoides/Sezary syndrome    
16p13 add(16)(p13) Myelodysplastic syndrome, NOS    
16p13 add(16)(p13) Myxofibrosarcoma Soft tissue  
16p13 add(16)(p13) Nodal marginal zone B-cell lymphoma    
16p13 add(16)(p13) Peripheral T-cell lymphoma, unspecified    
16p13 add(16)(p13) Pleomorphic rhabdomyosarcoma Soft tissue  
16p13 add(16)(p13) Refractory anemia with excess blasts-2    
16p13 add(16)(p13) Refractory anemia with excess of blasts (FAB)    
16p13 add(16)(p13) Squamous cell carcinoma Lung  
16p13 add(16)(p13) Squamous cell carcinoma Oral cavity  
16p13 add(16)(p13) Squamous cell carcinoma Larynx  
16p13 add(16)(p13) Synovial sarcoma Soft tissue  
16p13 add(16)(p13) Undifferentiated pleomorphic sarcoma Soft tissue  
16p13 add(16)(p13) Undifferentiated pleomorphic sarcoma Skeleton  
16p13 del(16)(p13) Acute erythroleukemia (FAB type M6)    
16p13 del(16)(p13) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
16p13 del(16)(p13) Follicular lymphoma    
16p13 der(16)add(16)(p13)add(16)(q24) Anaplastic large cell lymphoma, systemic type    
16p13 der(16)inv(16)(p13q22)t(10;16) Acute myelomonocytic leukemia (FAB type M4)    
16p13 der(16)inv(16)(p13q22)t(1;16) Acute myelomonocytic leukemia (FAB type M4)    
16p13 der(16)t(10;16)inv(16)(p13q22) Acute myelomonocytic leukemia (FAB type M4)    
16p13 der(16)t(11;16)(q13;p13) Diffuse large B-cell lymphoma    
16p13 der(16)t(1;16)(q10;p13) Multiple myeloma    
16p13 der(16)t(1;16)(q11;p13) Multiple myeloma    
16p13 der(16)t(1;16)(q12;p13) Diffuse large B-cell lymphoma    
16p13 der(16)t(1;16)(q12;p13) Multiple myeloma    
16p13 der(16)t(1;16)(q21;p13) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
16p13 der(16)t(1;16)(q21;p13) Acute megakaryoblastic leukemia (FAB type M7)    
16p13 der(16)t(1;16)(q21;p13) Multiple myeloma    
16p13 der(16)t(1;16)(q22;p13) Acute myeloid leukemia, NOS    
16p13 dic(12;16)(p11;p13) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
16p13 dic(7;16)(p11;p13) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
16p13 dup(16)(p11p13) Acute lymphoblastic leukemia/lymphoblastic lymphoma    
16p13 hsr(16)(p13) Acute myeloid leukemia, NOS    
16p13 r(16)(p13q24) Acute lymphoblastic leukemia/lymphoblastic lymphoma