Skip Navigation
National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools

Gene Info

Gene Information For:Hs. PKLR, Pyruvate kinase, liver and RBC
Sequence ID:NM_000298
NM_181871
RefSeqGene ID:NG_011677
Entrez Gene ID:5313
Ensembl ID:ENSG00000143627

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
ADENOSINE TRIPHOSPHATE,ELEVATED, OF ERYTHROCYTES 
PYRUVATE KINASE DEFICIENCY 

Cytogenetic Location (from UniGene)

Cytogenetic Location:1q21Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 155260087 - 155271225

 Exon Info From UCSC:
NM_000298
NM_181871

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5221697Full LengthBC025737pyruvate kinase, liver and RBC

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_870986  NP_000289  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000298 NP_000289 P30613 EC 2.7.1.40 PK
PK_C
NM_181871 NP_870986     PK
PK_C

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M15465 AAA60104 P30613 EC 2.7.1.40
S60712 AAB26262 P30613 EC 2.7.1.40
BC025737 AAH25737 P30613 EC 2.7.1.40
EU176228 ABW03679    
AB015983 BAA31706 P30613 EC 2.7.1.40
AK298399 BAG60632 B4DPM0  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PKLR NP_000289 R.norvegicus Pklr 24651   NP_036756 93
M.musculus Pklr 18770 Gene Info NP_038659 92
S.cerevisiae PYK2 854529   NP_014992 51
A.thaliana AT3G04050 819560   NP_187055 49
A.thaliana AT3G55650 824731   NP_191124 46
A.thaliana AT3G25960 822193   NP_189225 46
A.thaliana AT3G55810 824747   NP_191140 44

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database