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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. CDK4, Cyclin-dependent kinase 4
Sequence ID:NM_000075
RefSeqGene ID:NG_007484
Entrez Gene ID:1019
Ensembl ID:ENSG00000135446

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
MELANOMA, CUTANEOUS MALIGNANT, 3 

Cytogenetic Location (from UniGene)

Cytogenetic Location:12q14Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:12: 58142302 - 58146109

NM_000075 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
334285814200458142399
4295645814296458143099
5656155814323658143286
6167255814443858144547
7268935814470558144872
89410295814498958145124
103012665814528258145518
126714735814595758146163

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2961345Full LengthBC005864cyclin-dependent kinase 4
3531300Full LengthBC010153cyclin-dependent kinase 4
3532812Full LengthBC003644cyclin-dependent kinase 4

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000066  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000075 NP_000066 P11802 EC 2.7.11.22 Pkinase

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M14505 AAA35673 P11802 EC 2.7.11.22
U79269 AAB50213 Q6LC83  
BC003644 AAH03644 P11802 EC 2.7.11.22
BC005864 AAH05864 P11802 EC 2.7.11.22
BC010153 AAH10153 P11802 EC 2.7.11.22
BC015669 AAH15669 Q96BE9  
DQ893137 ABM84063    
DQ896420 ABM87419    
AK313701 BAG36447 B2R9A0  
AK297901 BAG60221 B4DNF9  
Z48970 CAA88834 P11802 EC 2.7.11.22
CR407668 CAG28596 P11802 EC 2.7.11.22
CR542247 CAG47043 P11802 EC 2.7.11.22

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens CDK4 NP_000066 M.musculus Cdk4 12567 Gene Info NP_034000 95

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database

BioCarta Pathways
Pathway information courtesy of BioCarta