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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. MPL, Myeloproliferative leukemia virus oncogene
Sequence ID:NM_005373
RefSeqGene ID:NG_007525
Entrez Gene ID:4352
Ensembl ID:ENSG00000117400

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
MYELOFIBROSIS WITH MYELOID METAPLASIA, SOMATICJAK2
SH2B3
THROMBOCYTHEMIA 1JAK2
SH2B3
THPO
THPO
THROMBOCYTHEMIA 2 
THROMBOCYTOPENIA, CONGENITAL AMEGAKARYOCYTIC 

Cytogenetic Location (from UniGene)

Cytogenetic Location:1p34Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 43803519 - 43818443

 Exon Info From UCSC:
NM_005373

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
100016416Full LengthBC153092myeloproliferative leukemia virus oncogene
100014304BC140298myeloproliferative leukemia virus oncogene

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005364  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_005373 NP_005364 P40238 fn3

Related Sequences

 
mRNAGenPeptSwissProt
M90102 AAA69971 P40238
M90103 AAA69972 P40238
BC140298 AAI40299  
BC153092 AAI53093  
DQ234353 ABB29982 Q308M1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens MPL NP_005364 M.musculus Mpl 17480 Gene Info NP_001116421 82
R.norvegicus Mpl 366455   XP_345573 77

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta