Skip Navigation
National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. SMAD4, SMAD family member 4
Sequence ID:NM_005359
RefSeqGene ID:NG_013013
Entrez Gene ID:4089
Ensembl ID:ENSG00000141646

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, salivary gland, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
JUVENILE POLYPOSIS SYNDROME, INFANTILE FORMBMPR1A
PTEN
JUVENILE POLYPOSIS/HEREDITARY HEMORRHAGIC TELANGIECTASIA SYNDROME 
MYHRE SYNDROME 

Cytogenetic Location (from UniGene)

Cytogenetic Location:18q21.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:18: 48556610 - 48605035

 Exon Info From UCSC:
NM_005359

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2961238Full LengthBC002379SMAD family member 4

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005350  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_005359 NP_005350 Q13485 MH1
MH2

Related Sequences

 
mRNAGenPeptSwissProt
U44378 AAA91041 Q13485
BC002379 AAH02379 Q13485
DQ891840 ABM82766  
DQ895028 ABM85954  
AK290770 BAF83459 Q13485

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens SMAD4 NP_005350 M.musculus Smad4 17128 Gene Info NP_032566 99
R.norvegicus Smad4 50554   NP_062148 99
D.melanogaster Med 43725   NP_733438 71
A.gambiae AgaP_AGAP002902 1273058   XP_311999 58

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database

BioCarta Pathways
Pathway information courtesy of BioCarta