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Gene Info

Gene Information For:Hs. PNP, Purine nucleoside phosphorylase
Sequence ID:NM_000270
RefSeqGene ID:NG_009631
Entrez Gene ID:4860
Ensembl ID:ENSG00000198805

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, nervous, ovary, pancreas, pancreatic islet, parathyroid, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
IMMUNODEFICIENCY DUE TO PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY 

Cytogenetic Location (from UniGene)

Cytogenetic Location:14q13.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:14: 20937568 - 20945242

NM_000270 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
11572093753720937693
1583272094046620940635
3284312094263020942733
4326072094293120943106
6087982094322020943410
79924132094454220946156

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3859664Full LengthBC106074nucleoside phosphorylase
40031416Full LengthBC104206nucleoside phosphorylase
40031417Full LengthBC104207nucleoside phosphorylase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000261  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000270 NP_000261 P00491 EC 2.4.2.1 Mtap_PNP

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
BC104206 AAI04207 P00491 EC 2.4.2.1
BC104207 AAI04208 P00491 EC 2.4.2.1
BC106074 AAI06075 P00491 EC 2.4.2.1
AK098544 BAC05327 Q8N7G1  
AK313490 BAG36272 P00491 EC 2.4.2.1
X00737 CAA25320 P00491 EC 2.4.2.1
CR407607 CAG28535 P00491 EC 2.4.2.1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PNP NP_000261 R.norvegicus Pnp 290029   NP_001099501 87
M.musculus Pnp 18950 Gene Info NP_038660 84
M.musculus Pnp2 667034 Gene Info NP_001116843 84
A.gambiae AgaP_AGAP005945 1276614   XP_001688760 56
S.pombe SPAC1805.16c 2542435   NP_593927 53
A.gambiae AgaP_AGAP005944 1276613   XP_315978 52
S.cerevisiae PNP1 850906   NP_013310 52
D.melanogaster CG16758 38315   NP_647727 51
C.elegans phosphorylase 176851   NP_499900 47

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)