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Gene Info

Gene Information For:Hs. JAK2, Janus kinase 2
Sequence ID:NM_004972
RefSeqGene ID:NG_009904
Entrez Gene ID:3717
Ensembl ID:ENSG00000096968

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
BUDD-CHIARI SYNDROMEF5
ERYTHROCYTOSIS, SOMATICEPOR
SH2B3
LEUKEMIA, ACUTE MYELOGENOUSARHGEF12
CBFB
CEBPA
CHIC2
ETV6
FLT3
GATA2
GMPS
KIT
LPP
MLF1
MLLT10
NPM1
NSD1
NUP214
PICALM
RUNX1
RUNX1
SH3GL1
TERT
WHSC1L1
MYELOFIBROSIS WITH MYELOID METAPLASIA, SOMATICMPL
SH2B3
THROMBOCYTHEMIA 1MPL
SH2B3
THPO
THPO

Cytogenetic Location (from UniGene)

Cytogenetic Location:9p24Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:9: 5021987 - 5126891

 Exon Info From UCSC:
NM_004972

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5556026Full LengthBC039695Janus kinase 2 (a protein tyrosine kinase)
5288207IncompleteBC043187Janus kinase 2 (a protein tyrosine kinase)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_004963  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_004972 NP_004963 O60674 EC 2.7.10.2 Pkinase_Tyr

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
AF005216 AAB82092 O60674 EC 2.7.10.2
AF001362 AAC23653 O60674 EC 2.7.10.2
AF058925 AAC23982 O60674 EC 2.7.10.2
BC039695 AAH39695 Q8IXP2  
AY973034 AAY22962 Q506Q0  
AK292525 BAF85214 A8K910  
AK302618 BAG63863 B4DYV1  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens JAK2 NP_004963 R.norvegicus Jak2 24514   NP_113702 95
M.musculus Jak2 16452 Gene Info NP_001041642 94

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database

BioCarta Pathways
Pathway information courtesy of BioCarta