Skip Navigation
National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. LRP5, Low density lipoprotein receptor-related protein 5
Sequence ID:NM_002335
RefSeqGene ID:NG_015835
Entrez Gene ID:4041
Ensembl ID:ENSG00000162337

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer Aberrations

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
EXUDATIVE VITREORETINOPATHY 4 
HYPEROSTOSIS, ENDOSTEAL 
OSTEOPETROSIS, AUTOSOMAL DOMINANT 1 
OSTEOPOROSISCALCR
COL1A1
COL1A2
IL6
PDLIM4
VDR
OSTEOPOROSIS-PSEUDOGLIOMA SYNDROME 
VAN BUCHEM DISEASE, TYPE 2 
[BONE MINERAL DENSITYVARIABILITY 1] 

Cytogenetic Location (from UniGene)

Cytogenetic Location:11q13.4Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:11: 68080079 - 68216646

 Exon Info From UCSC:
NM_002335

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
9056965Full LengthBC150595low density lipoprotein receptor-related protein 5
30527697IncompleteBC098397low density lipoprotein receptor-related protein 5

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002326  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_002335 NP_002326 O75197 EGF
Ldl_recept_a
Ldl_recept_b
NHL

Related Sequences

 
mRNAGenPeptSwissProt
AF064548 AAC36467 O75197
AF077820 AAC72791 O75197
BC150595 AAI50596 O75197
AB017498 BAA33051 O75197

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens LRP5 NP_002326 R.norvegicus Lrp5 293649   NP_001099791 95
M.musculus Lrp5 16973 Gene Info NP_032539 94
D.melanogaster arr 44279   NP_524737 46
A.gambiae AgaP_AGAP011770 1280870   XP_320740 44

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database