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National Cancer Institute U.S. National Institutes of Health National Cancer Institute
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Gene Info

Gene Information For:Hs. WRN, Werner syndrome, RecQ helicase-like
Sequence ID:NM_000553
RefSeqGene ID:NG_008870
Entrez Gene ID:7486
Ensembl ID:ENSG00000165392

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
WERNER SYNDROMELMNA

Cytogenetic Location (from UniGene)

Cytogenetic Location:8p12Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:8: 30948398 - 31031018

 Exon Info From UCSC:
NM_000553

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
9094347IncompleteBC172837Werner syndrome
9094348IncompleteBC172838Werner syndrome
9094349IncompleteBC172839Werner syndrome
9094350IncompleteBC172840Werner syndrome

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000544  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000553 NP_000544 Q14191 EC 3.6.4.12 DEAD
Helicase_C
HRDC
3_5_exonuc

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
AF091214 AAC63361 Q14191 EC 3.6.4.12
AY818673 AAX21098 Q14191 EC 3.6.4.12
AB209652 BAD92889 Q59F09  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens WRN NP_000544 R.norvegicus RGD1564788 290805   XP_002728460 73
M.musculus Wrn 22427 Gene Info NP_001116294 72
C.elegans wrn-1 174081   NP_495324 34

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database