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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. CASP8, caspase 8, apoptosis-related cysteine peptidase
Sequence ID:NM_001080124
NM_001080125
NM_001228
NM_033355
NM_033356
NM_033358
NM_033357
RefSeqGene ID:NG_007497
Entrez Gene ID:841
Ensembl ID:ENSG00000064012

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
ADENOCARCINOMA OF LUNG, RESPONSE TO TYROSINE KINASE INHIBITOR INBRAF
CYP2A6
DLEC1
EGFR
ERBB2
ERCC6
FASLG
IRF1
KRAS
MAP3K8
MAP3K8
PARK2
PIK3CA
PIK3CA
PPP2R1B
RASSF1
SLC22A18
BREAST CANCERAKT1
ATM
BARD1
BRCA1
BRCA2
BRIP1
CDH1
CHEK2
CHEK2
HMMR
KRAS
NQO2
NQO2
PALB2
PHB
PIK3CA
PIK3CA
PPM1D
RAD51
RAD54L
RB1CC1
SLC22A18
TP53
TP53
TSG101
XRCC3
XRCC3
HEPATOBLASTOMA, SOMATICAPC
APC
AXIN1
CTNNB1
MET
PDGFRL
PIK3CA
PIK3CA
TP53
TP53
IMMUNODEFICIENCY DUE TO CASP8 DEFICIENCY 

Cytogenetic Location (from UniGene)

Cytogenetic Location:2q33-q34Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:2: 202131209 - 202151315

 Exon Info From UCSC:
NM_001080124
NM_001080125
NM_001228
NM_033355
NM_033356
NM_033358

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
6421760Full LengthBC068050caspase 8, apoptosis-related cysteine peptidase
3852292IncompleteBC017031caspase 8, apoptosis-related cysteine peptidase
4092664IncompleteBC010390caspase 8, apoptosis-related cysteine peptidase
5217189IncompleteBC028223caspase 8, apoptosis-related cysteine peptidase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_203522  NP_203519  NP_203520  NP_001219  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001080124 NP_001073593      
NM_001080125 NP_001073594      
NM_001228 NP_001219     Peptidase_C14
DED
NM_033355 NP_203519 Q14790 EC 3.4.22.61 Peptidase_C14
DED
NM_033356 NP_203520     Peptidase_C14
DED
NM_033358 NP_203522     DED

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
AF009620 AAB70913 Q14790 EC 3.4.22.61
U58143 AAC50602 Q14790 EC 3.4.22.61
U60520 AAC50645 Q14790 EC 3.4.22.61
BC068050 AAH68050 Q6NVI2  
AF380342 AAK57437 Q14790 EC 3.4.22.61
AF422926 AAL87629 Q14790 EC 3.4.22.61
AF422927 AAL87630 Q14790 EC 3.4.22.61
AF422928 AAL87631 Q14790 EC 3.4.22.61
AF422929 AAL87632 Q14790 EC 3.4.22.61
EU168332 ABX09989 B6CGU5  
EU670044 ACF93415 C3S3G0  
AB451282 BAG70096 B5BU46  
AB451414 BAG70228 B5BU46  
X98172 CAA66853 Q14790 EC 3.4.22.61
X98173 CAA66854 Q14790 EC 3.4.22.61
X98174 CAA66855 Q14790 EC 3.4.22.61
X98175 CAA66856 Q14790 EC 3.4.22.61
X98176 CAA66857 Q14790 EC 3.4.22.61
X98177 CAA66858 Q14790 EC 3.4.22.61
X98178 CAA66859 Q14790 EC 3.4.22.61

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens CASP8 NP_001073594 M.musculus Casp8 12370 Gene Info NP_001073595 70
R.norvegicus Casp8 64044   NP_071613 68

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database

BioCarta Pathways
Pathway information courtesy of BioCarta