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Gene Info

Gene Information For:Hs. PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Sequence ID:NM_006218
RefSeqGene ID:NG_012113
Entrez Gene ID:5290
Ensembl ID:ENSG00000121879

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer Aberrations

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
ADENOCARCINOMA OF LUNG, RESPONSE TO TYROSINE KINASE INHIBITOR INBRAF
CASP8
CYP2A6
DLEC1
EGFR
ERBB2
ERCC6
FASLG
IRF1
KRAS
MAP3K8
MAP3K8
PARK2
PPP2R1B
RASSF1
SLC22A18
ADENOCARCINOMA, OVARIAN, SOMATICAKT1
CDH1
CTNNB1
OPCML
PARK2
BREAST CANCERAKT1
ATM
BARD1
BRCA1
BRCA2
BRIP1
CASP8
CDH1
CHEK2
CHEK2
HMMR
KRAS
NQO2
NQO2
PALB2
PHB
PPM1D
RAD51
RAD54L
RB1CC1
SLC22A18
TP53
TP53
TSG101
XRCC3
XRCC3
BREAST-OVARIAN CANCER, FAMILIAL, 1AKT1
BRCA1
MSH6
OPCML
PARK2
COLON CANCERAKT1
APC
APC
AURKA
AXIN2
BCL10
BUB1B
CCND1
EP300
FGFR3
FLCN
MLH3
NRAS
ODC1
PDGFRL
PLA2G2A
PTPRJ
SMAD7
TLR2
TLR4
TP53
TP53
GASTRIC CANCER RISK AFTER H. PYLORI INFECTIONAPC
APC
CASP10
CDH1
ERBB2
FGFR2
IL1B
IL1RN
IRF1
KLF6
KLF6
KRAS
MUTYH
HEPATOBLASTOMA, SOMATICAPC
APC
AXIN1
CASP8
CTNNB1
MET
PDGFRL
TP53
TP53
NEVUS SEBACEOUS, SOMATICFGFR3
HRAS

Cytogenetic Location (from UniGene)

Cytogenetic Location:3q26.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:3: 178953577 - 178955289

 Exon Info From UCSC:
NM_006218

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
8322653Full LengthBC113601phosphoinositide-3-kinase, catalytic, alpha polypeptide
8322655Full LengthBC113603phosphoinositide-3-kinase, catalytic, alpha polypeptide

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_006218 NP_006209 P42336 EC 2.7.11.1
EC 2.7.1.153
PI3_PI4_kinase
PI3Ka
PI3K_C2
PI3K_rbd
PI3K_p85B

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
U79143 AAB39753 P42336 EC 2.7.11.1
EC 2.7.1.153
BC113601 AAI13602 P42336 EC 2.7.11.1
EC 2.7.1.153
BC113603 AAI13604 P42336 EC 2.7.11.1
EC 2.7.1.153
DQ910907 ABI95433 Q06DD2  
HM437241 ADN43072 E2I6G1  
AB210020 BAE06102 Q4LE51  
AK292940 BAF85629 A8KA75  
AK297203 BAG59688 B4DLX6  
AK302608 BAG63856 B4DYU4  
Z29090 CAA82333 P42336 EC 2.7.11.1
EC 2.7.1.153

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PIK3CA NP_006209 M.musculus Pik3ca 18706 Gene Info NP_032865 99
R.norvegicus Pik3ca 170911   XP_001063573 98
C.elegans age-1 174762   NP_496462 32

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database

BioCarta Pathways
Pathway information courtesy of BioCarta