Skip Navigation
National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. HLA-DRB1, Major histocompatibility complex, class II, DR beta 1
Sequence ID:NM_002125
RefSeqGene ID:NG_002392
Entrez Gene ID:3123
Ensembl ID:ENSG00000196126

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
MULTIPLE SCLEROSISCD24
CIITA
HLA-DQB1
HLA-DQB1
IL7R
PDCD1
PTPRC
RHEUMATOID ARTHRITISCD244
CIITA
IL10
NFKBIL1
PADI4
PTPN22
RUNX1
RUNX1
SLC22A4
STAT4
STAT4
SARCOIDOSIS, ,1BTNL2
NOD2

Cytogenetic Location (from UniGene)

Cytogenetic Location:6p21.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:6: 32485503 - 32557563

NM_002125 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
133793248516232485528
3804033248583032485853
4045143248633232486442
5157963248714632487427
79710663248968132489950
106711713249790132498005

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4272571Full LengthBC008403major histocompatibility complex, class II, DR beta 1
4309837Full LengthBC007920major histocompatibility complex, class II, DR beta 1
4695321Full LengthBC031023major histocompatibility complex, class II, DR beta 1
4852401Full LengthBC024269major histocompatibility complex, class II, DR beta 1
5216243Full LengthBC033827major histocompatibility complex, class II, DR beta 1
40023604Full LengthBC108922major histocompatibility complex, class II, DR beta 1

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002116  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001243965 NP_001230894 P01912  
NM_002124 NP_002115 P04229
P01911
MHC_II_beta
C1-set
NM_002125 NP_002116 Q30154 MHC_II_beta
C1-set
NM_021983 NP_068818 P13762 MHC_II_beta
C1-set

Related Sequences

 
mRNAGenPeptSwissProt
U09201 AAA17992 O19622
M15178 AAA35995 P13762
M11867 AAA36274 Q5Y7B6
P20039
M16954 AAA36276 Q30154
M16955 AAA36277 Q30154
M16956 AAA36278 Q29789
M16957 AAA36279 P01911
M16958 AAA36280 Q29791
M16959 AAA36281 Q29974
M14190 AAA36288 O19727
M14191 AAA36289 O19728
M17383 AAA36294 Q30147
M17384 AAA36295 Q30148
M16942 AAA36296 P13762
M17388 AAA36299 O19740
M17385 AAA36300 Q30152
M25266 AAA57259 Q30164
M25265 AAA57260 Q30165
M15992 AAA59678 Q29972
M16086 AAA59679 Q29973
M28583 AAA59680 Q29974
M28584 AAA59681 P01911
M30180 AAA59714 Q30008
M30182 AAA59715 Q30009
L02545 AAA59777 Q29974
M21008 AAA59780 P04229
M11161 AAA59781 P04229
M33600 AAA59782 P04229
M26038 AAA59794 Q30134
M32578 AAA59795 Q30109
M14661 AAA59799 Q30136
M14662 AAA59800 O19730
M17378 AAA59801 P01911
M17379 AAA59803 Q30143
M17381 AAA59805 P13760
M15069 AAA59809 P13760
M15074 AAA59810 Q30134
M15071 AAA59813 Q9NQ54
Q9GIJ6
O19743
Q9GJ49
O19738
O19719
Q9MYE4
M17377 AAA59818 Q30154
M17382 AAA59819 Q30151
M20429 AAA59822 Q30154
M16732 AAA59825 Q9NQ54
Q9GIJ6
O19743
Q9GJ49
O19738
O19719
Q9MYE4
M20503 AAA59826 Q30158
M20504 AAA59827 Q29974
M27689 AAA59829 Q30162
M20430 AAA59831 P01911
M20138 AAA59832 Q30167
M30181 AAA59840 Q30178
M30179 AAA59842 Q30179
M57648 AAA63218 Q29971
M59798 AAA64236 Q30114
M59803 AAA64237 Q5Y7A7
L42143 AAA67104 P13760
Q70Q10
U35375 AAA75373 Q29717
U35729 AAA79144 O19190
U37582 AAA79205 Q13365
M27635 AAA81550 Q29901
S48645 AAB24005 Q95465
AF004817 AAB61608 O02951
U29342 AAB63410 Q29696
U37433 AAB63411 Q29726
U47028 AAB63412 Q29745
U31770 AAB63983 Q30154
AF017439 AAB70553 Q95IE3
AF017440 AAB70554 O19586
AF017441 AAB70555 O19587
AF010142 AAB81176 O19517
U56640 AAC02715 Q95379
AF048707 AAC31951 O78117
U17379 AAC50165 Q29671
U17381 AAC50167 Q5Y7A7
U95817 AAD00817 Q9TQD9
U95818 AAD00818 Q9TQD8
S79786 AAD14315 Q29754
U65585 AAD43827 Q9TQE1
U66826 AAD43829 Q9TQE0
BC005312 AAH05312 P13762
BC007920 AAH07920 Q5Y7A7
BC008403 AAH08403 Q95IT4
BC009234 AAH09234 Q30154
BC024269 AAH24269 Q8TB62
BC031023 AAH31023 Q8NEI3
BC033827 AAH33827 P01911
BC108922 AAI08923 P01911
AF291675 AAK91825 Q95IH1
AF436097 AAL30416 Q95HL8
L76133 AAL40069 Q5Y7A7
AF361548 AAM00252 P13762
AF361549 AAM00253 P13762
AF490771 AAO85467 Q860Y4
AY770514 AAV28303 Q5XKU0
AY626551 AAV34808 Q95IE3
AY935719 AAX33315 Q9GIY3
AY961062 AAX63450 Q8TB62
AY961063 AAX63451 Q70Q10
AY961064 AAX63452 P01912
Q5Y7D1
AY961065 AAX63453 Q56FP7
AY961066 AAX63454 Q5K3W3
AY961067 AAX63455 Q56FP5
AY961068 AAX63456 Q95IH1
AY961070 AAX63458 Q5Y7A7
AY961072 AAX63460 P01911
AY961073 AAX63461 P01911
AY961076 AAX63464 Q56FN6
AY961077 AAX63465 Q56FN5
AY961078 AAX63466 Q56FN4
DQ002917 AAY21682 Q4ZJJ2
DQ090958 AAY96423 Q4JH26
Q30134
DQ140279 AAZ76539 Q0R326
DQ284431 ABC66198 P13762
DQ284433 ABC66200 Q2LIR4
GQ891550 ACX50637 P13762
HQ447115 ADQ31602  
HQ447401 ADQ31887  
D86415 BAA13086 Q29769
AB062112 BAB84521 Q9GIY3
AK289463 BAF82152 P04229
AK291499 BAF84188 A8K634
AK291987 BAF84676 Q29974
AK292140 BAF84829 Q0R326
AK292151 BAF84840 P13762
AK293020 BAF85709 Q5Y7A7
AK314834 BAG37353 Q30154
X00699 CAA25295 P01912
Q5Y7D1
X00700 CAA25296 Q30167
X02902 CAA26660 P13760
X03069 CAA26873 P04229
X99895 CAA68170 Q95462
AJ297582 CAC08822 Q9GIY3
AJ297583 CAC08823 Q9GIY3
AJ297585 CAC08825 Q9GIY3
AJ297586 CAC08826 P13760
AJ297587 CAC08827 Q5Y7G6
P20039
AJ580838 CAE45568 Q70I25
AJ697892 CAG27025 Q5K3W3
AJ697893 CAG27026 Q5Y7A7

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens HLA-DRB1 NP_002115 M.musculus H2-Eb1 14969 Gene Info NP_034512 76
R.norvegicus RT1-Db1 294270   NP_001008884 73

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

NCI-Nature Pathway Interaction Database

BioCarta Pathways
Pathway information courtesy of BioCarta